PhilGeis
Forum Replies Created
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Try them together.
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Do ingredients in your formula hold the pH steady or is pH readily adjusted?
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@DeepTitan
Antiaging is marketing claim in Western world. Can you provide some links the ancient Chinese concept -
Guess I can see it happening in a country that desires to directly control thought and a population unsophisticated in the hyperbole (or worse) of cosmetic marketing.
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@DeedeeUkulele
Please note Glucosamine instability @37C in the cited article appears to be in context of come concentration of ammonia and phosphate buffered to an (in abstract) pH. Can’t access the paper itself - any idea what these other specifcs were? -
Foods? Weak materials with a lower bare of efficacy and regulatory and safety bars even greater.
The best - maybe only - Lanxess and prob more so Arxada.
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Sure - Schulke, (former Dow) Microbial Control, Lonza, Emerald Kamala.
To new classes - no. For perspective, a major effort was mounted a 4 or 5 years back organized by Green Chemical and Commerce Counsel (“3G”) and funded by the major companies - P&G, Unilever, etc. to find new preservatives. It was a complete bust - nothing identified worked. Here’s the very political report observing how well industry played together, completely ignoring the total failure of the effort.
https://www.sciencedirect.com/science/article/abs/pii/S2352554120305696I was contracted couple of years backas technical review by a major company for submissions responding to a similar search. Again nothing new of substance.
Development of novel solutions/chemicals clearly need critical financial and technical mass not found in academic and startup entities.
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Geogards are hardly benchmarks.
Two major companies, Lanxess and Arxada, have respectively acquired multiple former preservative development companies with the nominal objective of novel development.
It really takes companies of size to address adequately efficacy, (most importantly) safety and regulatory demands (e.g. EU cosmetic directive) of novel development.
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Are you buffered?
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Can you get Aw?
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What is the effective water %? Can you get an Aw?
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As Pharma noted, it can be both the microbe and its products. You may also find pink with less-common contaminants Chromobacter and contaminating fungi - esp. yeastlike fungi Rhodotorula.
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Yes you can leave it at 3.8. But why did you think you needed to increase it and to what pH?
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what pH do you want to establish?
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No. Recall it’s not that effective in product.
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9010 is not enough - you should add something for fungi.
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To the contracts and NDA’s - do not be afraid to push back - even lining out offending sections with initials and dates. I often find clients have little idea what is actually in the documents have me sign and explaining the change is usually no issue. One common boiler plate issue is indemnification and “don’t worry, we’d never do that” is not acceptable.
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As Paprik suggested it might be contamination. Get it tested.
No water ingredient listed ,and you need to label the chemical ingredient, not the commercial name. -
@Newtoformulating
I understand. Preservative marketing is a pain. So many combinations with similar names, many of which are +/- useless. -
Right - that should work well - esp at near neutral.
@Abdullah - I don’t know enough to address gentle and pH. -
Don’t think all ingredients must be food grade but not up on food reg’s. Iodized salt is obviously used as a direct food ingredient but prob more expensive than without. suppose you could use GRAS spec if concerned.
Off target from your question - what is your preservative? -
Nothing that is appropriate and could be called “natural” comes to mind.
MSDS/SDS focus is hazard, and figure Homedepot guys know their OSHA. -
USP grade is not needed for this application. But you should know composition.
pH of dishwashing liquid is typically alkaline (Dawn is 9) as adjusted by e.g. NaOH.
“Tap” water pH is usually slightly alkaline but can be highly variable. EPA secondary drinking water standards specifies 6.5-8 https://www.epa.gov/sdwa/drinking-water-regulations-and-contaminants -
You’d need up to 20% ethanol; sorbate requires pH control and isn’t registered; citric acid is not a preservative. Whatever you use, it has to be safe for inhalation. Target is largely fungal and Gram positives. You’re likely using water of whatever quality, and glycerol largely stops growth rather than kill.
Maybe benzalkonium Cl (BAK), commonly used in nasal sprays tho pH might be a bit low - bet there’s a registered preservative version. I recall using DMDM hydantoin in spray-on hair conditioner - cleared by comp. toxicologists but safety is on you. There is a registered version. Neither BAK nor DMDM Hydantoin is that great vs fungi. But safety is on you.
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US then - prob never get caught, but law requires preservative to be registered with EPA. Dolt think DHA is and 2-5 ppm is pretty useless.
30% glycerol is pretty simple - can you make it fresh for every use? Think the Aw should be around 0.9, so some protection.