PhilGeis
Forum Replies Created
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If you‘re +/- duo - prob makes no diff but should sanitize with hypochlorite.
If manufacturer to any significant volume, get rid of the plastic, add separate sanitizing step, if liquid detergent make sure it’s not contaminated.
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1 and 3 are little more thanphenoxy and marketing.
Divalent cations (this context)Salts of organic acids can mitigate their limited solubility/efficacy
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That is a pretty poor preservative system at any pH.
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Similar reports for Avons Skin
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Old system allowed a great number of discussion posts on screen at one time - this one allows fewer
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FDA improved (finally!) their previous (really crappy) Chapter 23 BAM for cosmetics QC ~decade ago but it’s still kinda flakey. Suggest relevant ISO’s, CTFA’s. or even USP 61/62.
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Looks like some lily-livered scoundrel bushwhacked him!
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@Microformulation
They received > 200 questions. hope they’ll answer those they can -
@MarkBroussard
Sorry Mark - you would have found it interesting.
Nope. That’s on FDA’s list of development items. They emphasized product in place of ingredient but suggested ingredient news could screw up a product assessment. -
Don’t know if you guys sat in - some points cam across to me that folks here should understand
- safety that all must substantiate is for product, not ingredients per se
- adverse event reporting can be by website - assume company’s website as in
“none reported”
- FDA recall authority is for Class I recalls, the most serious - almost all
cosmetic recalls are the less serious classes II or III.
- A lot of stuff is hanging fired until FDA sets up the regs - GMP’s big sand small business, fragrance allergen labeling (but might go to school on EU) -
Today!
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It’s used in cosmetics soaps typically as tallowate - FDA does not have authority over pure soap.
if your concern is for BSE - see: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=700.27 -
your water phase pH?
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What presrvative do you propose?
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Adding to ngarayeva001’s good comment, be aware you may have trouble passing a preservative test whatever preservative you use as inoculum droplets may not encounter water droplets with preservative. That should not be considered a show stopper.
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@BUNSEN87
Sure - “trend” means exploitation of consumer ignorance that sells ingredients with little safety information and rejects those whose safety is well established. -
Aw tells you the risk in use. Your primary risk is humidity and fungi. Packaging must protect vs. direct water addition.
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There is no challenge test that’s appropriate and applying aq. product standards is not appropriate.
Your worry is growth of fungi - if its wet enough for bacteria, you haven’t a chance. Get the lab to run AW (water activity) on product held at humidified conditions.
What is the pres system you’ve tried? -
The final product is an anhydrous powder? How are you testing it for preservation, and what is bioburden of the rice starch?
Think you need to generate some in-use data - not only direct water contamination but taking up water from humid shower environment.Please drop the “too much food’ context - bacteria can grow in distilled water and fungi on basement walls.
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Micro testing: content to spec and, if you’ve not conducted it, stability testing.
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Thanks Mark
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Meant that a claim of “quality ingredients” is meaningless - no one should use poor quality ingredient.?
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@Ghita37
It just more meaningless advertising. Every one (definitely better) use quality ingredients. -
@Ghita - that one is a weak chelator that can inhibit fungi.
Leave-on versus rinse off products typically have different preservative systems.
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@blueberry
I’d not count on rinse-off products offering much benefit in that regard.