• Formulating

  Inactivation of Phenoxyethanol by Polysorbate 20

  Posted by VinTec on February 28, 2023 at 5:21 am

  Hi there!

  I was talking with a colleague and he told me that Polysorbate 20 innactivates Phenoxyethanol. Does anyone knows if that’s true? I know that some non-ionics (PEGs) surfactants can innactivate some types of preservatives, but I’m not sure about the percentage of polysorbate 20 that can (maybe) innactivate phenoxyethanol. I’ll continue to do my research, but it would be great if anyone could share information or resources about that topic!

  Thanks in advance 😊

  Kind regards.

  PhilGeis replied 1 year, 1 month ago 3 Members · 3 Replies
• 3 Replies

• 

  MarkBroussard

  Member

  February 28, 2023 at 7:59 am

  If I recall correctly, the main issue with Phenoxyethanol are non-ionics, but it is also possible that Polysorbate is used as a neutralizer in conducting PET.

  • 

    VinTec

    Member

    March 16, 2023 at 7:03 am

    Thank you, Mark!

    I’ll try to conduct more research on this topic. 🙂

• 

  PhilGeis

  Member

  March 16, 2023 at 8:36 am

  Mark is right. The nonionic Polysorbate (Tween) 80 is used as preservative neutralizer in finished product micro testing. It may or may not have the same effect as ingredient in finished product formulation,

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