Sibech
Forum Replies Created
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@saraahsan without a formula written down no one here will be able to tell you better than “maybe”.
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ngarayeva001 said:Guys I read a review in the Advanced Cosmetic Formulators group on Facebook and it sounds like that dynamix isn’t particularly good with high viscosities. Sounds like it’s just an overpriced stick blender
I mean, you’re not wrong, but if you already consider buying a bamix you’ve set the pricepoint fairly high (for a stickblender) already.
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@Pharma I agree that chemical nomenclature is easier to deal with. And of course, there are exceptions (Trilaurin for instance) I was basing my question more on the INCI guidelines and other mixed compounds (completely disregarding “impurities”).Regardless, I don’t think they have applied for an INCI name if that is the case (I checked PCPC, and even limited it to just include everything with “docosahexaen” in the INCI name) - No results.
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@pharma You’re welcome!
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If you are going to invest in a new blender such as a Bamix for emulsions, there is also another possibility.Dynamic Mixers have a variable version with 3000-13000 RPM and ablender/homogenizer attachment they usually cost around 200€ for the “home”-version with both (DYNAMIX® DMX 160 blender / homogenizer)
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Pharma said:Docosahexanoic acid aka DHA is a trendy and healthy omega-3 fatty acid. Your ominous compound might be glyceryl tridocosahexanoate/oleate i.e. a triglyceride containing DHA and oleic acid at mixed ratios…Whoop - I forgot to mention (or think about) the possibility of reaction mixtures in my “only one oate/eate part” (I blame the heat we’re currently experiencing here 😉 ).I think suggested mixture of DHA and Oleate triglycerides would be either: Docosahexaenoic/Oleic Triglyceride for a fully substituted glycerol moiety or alternatively glyceryl docosahexaenoate/oleate for mixed monoesters rather than glyceryl tridocohexaenoate/oleate.
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Can you use it? yes in principle you can use it, however, those formulations are intended mostly as inspiration and guidance.As for what would you have to do to get it to market?Well, that depends on where you live. It is a sunscreen which is anywhere between a drug and a cosmetic depending on where you live. This means you would also (depending on where you produce and sell) have to do various registrations, toxicological assessments. In addition, you would need to do stability tests, efficacy tests, packaging compatibility tests, SPF tests (this needs to be done at a certified lab no matter the region you want to sell in).If you were to sell any sunscreen product I would suggest getting together with a contract manufacturer to do the production for you - and they would likely tweak the formulation to fit their production of it.
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The reason you cannot find it is probably because it is an invalid INCI name.First of all, if this was an actual INCI name, there would be no space between “tri” and “docosahexaenoate”. In addition, there can only be one “oate”/”eate” (acid-derived moiety/anion in naming) as part of ingredients.Which product did you find it listed in because and was it on the packaging or on a website you got this “ingredient name”?I did a google search, found that supposed INCI name on websites only but when you looked at the packaging it was nowhere to be found. In all the cases (4) when finding an image of the product the label had Glyceryl Oleate instead of “tridocosahexaenoate oleate”.
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abh032000 said:hahaha, I unfortunately don’t have the entire formula yet either..what about if there’s any high intensity oil solubles natural sweetners?
Well, you don’t have the entire formula yet, otherwise, you wouldn’t need to adjust it right now at all. You really should listen to Pharma and Ngarayeva001 and post the formula (in its current state) with INCI names (and possibly tradenames) and their percentages. Your current process should be added too so people can see if you’re making some odd choices that could increase any off-taste.
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I’ve seen an “oil-free” moisturizer with squalane as one of the first ingredients. But oil can (as it does not have a regulatory definition in regard to cosmetics) defined in many ways, and is basically a meaningless claim.
Are oils all lipids? Vegetable oil? Paraffinum Liquidum? Free fatty acids? Alkanes? All organic and water immiscible compounds liquid at room temperature? (for anyone may find this later on at a whim, organic is meant in the chemical sense…)
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Yes, remember that when you are filling the container you are adding the propellant through the exit valve and under pressure the gasses which are used as propellants are liquid.
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@janele Pentavitin is an isomerate of D-glucose mostly consists of glucose and fructose (Besides water).
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@akuatajaThick is a very broad term and defining what you want to achieve might help you get some responses (Do you want to suspend something? is it just thickening? must it be a clear gel?)For a gel with only one thickener, I would go with the dehydroxanthan gum - It does however not gel enough to suspend particles and is more sensitive to electrolytes than regular xanthan gum, so beware of that.You might also want to try a multi-component gel (Binary often good enough great, meaning you use two gelling agents). As Pharma mentions Xanthan has synergies with Locust bean gum and “similar gums” - similar gums are galactomannans and guar, fenugreek and tara gum also fall in the same category.edit: formatting
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@Peppas_I basically you package the formulation to a cannister, add the dip tube-cap with a casket & seal it, then add the propellants afterwards (pumping them into under pressure).
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Not legally in the EU, no.
but remember the category 1 compounds also need the additional criteria you mentioned in your first post. -
Article 15 is not as such about restricted substances but is about the ban and exemptions to this ban of CMR chemicals (Carcinogenic, Mutagenic and toxic to Reproduction).
Basically, it tells you that compounds that are classified as CMR compounds according to the REACH chemical legislation are prohibited.
If they are approved by the SCCS as safe for category 2 compounds they can still be used. If they are category 1A or 1B they need to have additional criterions included for the safe and legal use.
To have the SCCS develop an opinion, then the EU commission need to request (mandate) a such opinion.
There are diverging opinions on how the legal text should be read, and a few EU countries consider the ban in effect from the moment a compound is harmonized in the EU as a CMR compound. The EU commission however considers it to be understood as needing to be banned (placed on Annex II) within 15 months of the CMR registration and after this point only would be banned.
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@chemicalmatt - Valid point - Isn’t the psychedelic yellow of the vitamin Bs Riboflavin?
Regarding the colour you will get from cyanocobalamin, it actually depends on the oxidation state of the cobalt atom. Pink is the natural state Co(III) & Yellow-ish is Co(II). Where Co(III) is the natural state in B12.
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As for your question on buffer and pH, this might be useful even if it was for an injectable solution. a pH of 4.3 and an acetate buffer was used with the highest level of succes.
https://jpharmsci.org/article/S0022-3549(15)34243-X/pdfIncompatibilities may include ascorbic acid. http://europepmc.org/articles/pmc4179674
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@Doreen While it is only done in vitro, B12 worsened the pathogenic factors for acne patients, as the pathogenic strains produce a significantly higher amount of Porphyrins, of which B12 is basically giving them a shortcut. The porphyrins when excited (by UV) cause oxidative damage and allow for growing space in the pore.Now I have no clue if topical application of cobalamines would cause any worsening in vivo (I’ve found no studies indicating anything here), but I thought you might want to know anyway!
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@gunther - According to their patent (US6638497B2), the function of glycols in their strong quats are to reduce the melting point of the mixture, so as to reduce heating time and potential for thermal degradation of the quat.
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It is a trend on the rise, but one where you really need to be careful as individual countries have vastly different regulations concerning CBD. It is an export jungle, to put it mildly.I’m curious though, is the main product type you have formulated with CBD regular creams?
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@Bill_Toge Yes - I quite like the EmoGreen products as well, but even there I found a need to mix the L15 and L19 to get a closer approximation to D5 in terms of volatility/silicone-oil-feel.
Specifically, I was doing a hair serum - and well, D5 always worked wonders there. -
,"y":325,"w":492,"h":19,"abs_x":384,"abs_y":1318}”>In a word. No.
,"y":344,"w":492,"h":19,"abs_x":384,"abs_y":1337}”>
,"y":344,"w":0,"h":18,"abs_x":384,"abs_y":1337}”>,"y":363,"w":492,"h":76,"abs_x":384,"abs_y":1356}”>In a few more words; You can get a very close approximation, but usually with a mixture of other ingredients (alkanes of various sort for instance) but they are much more expensive and you will likely never find a 1:1 substitute.
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I don’t know if Acudyne 1000 would work (I have not worked with it before) - My best suggestion is to try it, probably in a similar or slightly lower concentration as you would a non-aerosolized spray formulation.
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Welcome to the forum.If you want it to give any texture you would have to add some hold-giving polymers (VP/VA for instance), otherwise, it would just be a matte-effect powder.A hair powder with texturizing effects sound a lot like something out of Evonik’s Aerosil silicas, and it is therefore important to mention - not all silicas are equal. Aerosil R 202 and Aerosil R 802 are good for dry water formulations.Basically, you create your water phase, then under high shear mixing, you blend in the silica until you have a dry product. (In the lab, a blender or a disperser blade is useful).As for preservation - assuming you can create a formula with the ingredients you described, then strictly speaking, no. There is not any water and therefore microbial growth is not likely. I would still add some, however, in case people keep it somewhere moist.