PhilGeis
Forum Replies Created
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Use by date - on what would you base that and can you say more about “manufacturer guidelines.”
In what country will you sell?
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Chelators are not equal. Like preservatives, subordinating a functional ingredient to serve a secondary claim is not without risk. All you have to judge is a PET test too blunt to dissect that risk.
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For preservation (booster) - WITH a preservative. Those are good preservative systems and EDTA enhances.
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For preservation - yes.
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Bacterial spores and spores of many fungi will not be killed. There isn’t a good answer for speed of kill for other/vegetative cells but you can’t count on complete kill.
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These are really poor “boosters” - esp. vs Gram negatives and their esterases.
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What standard are you using for PET? Don’t think either USP 51 nor EP has relevant day 7 for what I’d assume is your category. Doesn’t change the need here for better preservation that might be better served with a paraben.
Suggest you review what’s used in marketed products - esp. US where I think 501k filling is needed.
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Gamma irradiation is the best method for clay. Dry heat 180C for 2-3 hours would theoretically do it - if you get penetration and the material is dry.
Please don’t use “nasties” - no need for the mommy blog BS.
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zetein said:@PhilGeis Can the cationic surfactant in conditioner be relied on for anti-microbial? If yes, what should the concentration and pH be?
Nope tho some might have a small effect, none adequately preserve. Note Downy and others with enough cationic to work through the wash still need preservatives.
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Claim is at best mislabeled - they could call it “blessed” with the same accuracy. More importantly, how is it assured? Is there a rip off org like EWG that extorts to condifrm?
Confident that brief UN description took years, millions of dollars and extensive travel by authors to produce.
EU, US and major nations generate their own policy and those are largely picked up by smaller nations if they bother, not UN’s. -
Sorbate is so weak and the others are 100% useless as “preservatives”. This is not hurdle - it’s total BS.
Maybe they found this passed USP 51 - hardly a recommendation. One needs to design a system that should work and confirm efficacy with 51. 51 by itself is not a valid test for efficacy.
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Sorbate alone is not useful and 0.1% is stupid.
Plastic - polyethylene? flip top or screw off?
Heat - how high and is it packed out hot/warm? -
Personal protection equipment for you - eye shields etc.
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Use PPE
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Your biggest issue is with Gram negatives. Wish you could use isothiazolinones - failing that phenoxyethanol or benzyl alcohol at ~0.5%. Don’t see too much purpose in multiple organic acids - DHA has the most favorable pKa but I worry about stability. Think you also need a chelator - EDTA, phytate.
What kind of process and package? -
pH ?
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UN bureaucracy sticks its fingers in everything.
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Dilute soap - any heat in prep? If water is in control and small batches, prob not with effective cleaning and sanitization.
If preservative needed - try benzoisothiazolinone (e.g. Proxel) or Gylcoserve (DMDM Hydantoin). -
And unless your putting mica back, it’s nor more sustainable than petroleum production.I suppose we can think of this claim as puffery. As typically used, “sustainable” is j.ust that
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You can - but the combination is not great. Benzyl or phenoxy with benzoate AND a chelator will do well in a shampoo. But “natural”
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How is mica sustainable?
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Phenoxyethanol at 0.5% and Na benzoate at 0.26%.
Amen to my colleague Abdullah’s comment!
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Right - use (e.g.) benzoate with Euxyl PE 9010. “Broad spectrum” is largely marketing so be cautious when you see it.
Phytate/Euxyl K903 is ok, esp. in surfactant products. Geogard ECT not so much and do not use Linatural 3. - PEA partitioning is an issue, esp. in smaller packages and with implements (e.g. mascara brushes).
Whatever you use, make sure you show efficacy in final packaged stability.Propanediol vs Glycerine is nothing to count on.
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This is a drug product in the US, subject to the same regulatory , quality and manufacturing requirements of any drug.
FDA has given temporary relief during covid - in this they specify WHO ethanol standard of 80%
https://www.fda.gov/media/136118/download