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Tagged: formaldehyde, formaldehyde-donors, preservative
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How, when and why do formaldehyde donors release formaldehyde?
Posted by Abdullah on November 27, 2021 at 2:45 pmSuppose DMDM hydantoin for example in a Shampoo formula. It has formaldehyde but it is not free at first.
Here are some questions.
1. Does it releases the Formaldehyde by Time? For example release specific percentage each month until all of them are released?2. Does it release formaldehyde when it is needed? For example if it gets contaminated it releases some formaldehyde to kill the microbes and if didn’t get contaminated don’t release formaldehyde too?
3. Or it has any other plan on when to do or don’t release formaldehyde?Abdullah replied 1 year, 6 months ago 3 Members · 10 Replies -
10 Replies
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it releases formaldehyde when microbes attempt to ingest it, in the same way that parabens release alcohols when microbes attempt to ingest themit also starts to release formaldehyde in alkaline conditions, or when exposed to temperatures over around 50-60 °C
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Bill_Toge said:it releases formaldehyde when microbes attempt to ingest it, in the same way that parabens release alcohols when microbes attempt to ingest themit also starts to release formaldehyde in alkaline conditions, or when exposed to temperatures over around 50-60 °C
Thanks
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@PhilGeis the fact that neither 5,5-dimethyl hydantoin (the parent compound of DMDM hydantoin, minus the two formaldehyde equivalents) nor p-hydroxybenzoic acid (the parent compound of parabens) have any microbistatic or microbicidal activity is pretty strong evidence
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Bill_Toge
That closely related compounds have no efficacy is no proof, strong or otherwise) of bacterial “attempt to ingest” as some controlling mechanism. Where are the compelling data?
Formaldehyde releasers maintain 100-200 ppm formaldehyde - an effective level with or without bacteria. One can can temporarily recued that level by dialysis and it will be reestablished in a day or so.
Parabens are sensitive to esterases - why so poorly effective vs. Gram negative that often proceed to degrade the rest of the molecule. These are extracellular - as are esterases in skin that also degrade the parabens. -
Do not have that information. Experience - at use levels of ~2500 ppm - 100-200 ppm “free” formaldehyde.
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2500ppm DMDM hydantoin correct?
How did you check or know what percentage of formaldehyde is free?
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Analytically. This was needed to stay under EU cosmetic directive labeling re. contains formaledehyde.