PhilGeis
Forum Replies Created
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True soap-based shampoos were replaced by synthetic surfactant-based products in the 1930’s.
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Assume you’re looking at the skin protectant monograph.
What is your intent for the glycerine use? -
By definition, “intent” establishes a drug product. Product claim is the most obvious indicator of intent. As Rockstargirl noted - and you see it in antiaging products with wrinkles, etc. - addressing “appearance” can be a means of maintaining cosmetic status.
In US, simple “soap” (as the metallic salt of a fatty acid) is an article regulated by EPA and CPSC not a cosmetic. Surfactant based soap is a cosmetic.For OTC drugs, read the relevant monograph. Some require testing to confirm efficacy. https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm
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pH 6 with sodium benzoate?
Micro may not be the source of your immediate concern - but that is a useless preservative system. -
Antimicrobial toilet paper (Triclosan).
Might add any/maybe all of the latest Microban applications. -
[PDF] Prevalence of Moderately Halophytic Aerobic Gram Positive Cocci in Bath Soap Bars wS Témoin‐Fardini, J Servant… - International Journal of …, 2017 - Wiley Online Library
… strain DSM-12544 purchased was not able to predict the ability of contamination of an
alkaline soap, the wild-type strain Nesterenkonia lacusekhoensis 768 was chosen to be our ‘…[PDF] academia.eduith Special Reference to Nesterenkonia Species
Z Bhathena, N Barchha, TK Sivaram - academia.edu… Thus, in this study 20 unbranded soap bars available in local … to the lesser known
Nesterenkonia species, an alkalophilic … closely related to Nesterenkonia species. Thus, survival of … -
I’ve no specified number. My experience has been in shampoos and hand wash.
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Groan! Spaghetti bomb>
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%
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I’d test that one as prototype.
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Yes - but I’d not bother with mold for surfactant products.
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What are chances of freezing in your distribution system?
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Suggest at minimum you use CTFA method. In any case, preserve for complete elimination in 7 days or less, not the %’s.
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Sort of - sterile water but sending it for testing won’t work. Bugs can grow in transit.
Ask the supplier about package quality. -
Run micro of rinse water of a few lots.
Also - ask the supplier. -
No need and likely not feasible to sterilize. They should be clean - if you have the resources, check micro content on samples of a few lots.
Exception might be pumps - if preprimed or tested, may have residual water and that will have bugs. These can’t be sterilized - work with supplier to stop the practice or rinse with alcohol. -
Suggest one of Abdullah’s suggestions with EDTA and benzoate.
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You should understand water loss that can throw you into net weight noncompliance. http://www.qic-intl.com/glossary/MAV.htm
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If your name is one the product, you are responsible. A contract packer would be responsible for issues associated with manufacture - contamination, adulteration, etc. for which you would sue them.
I’d ask - if they do not have liability insurance, do not work with them. -
SDS refers risk associated with the raw material. to address risk in product application, one would need to consider dose - as Perry noted in the initial post..
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what is your pH?
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Gluconate isn’t much of a chelator - use NaEDTA
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@Graillotion
IPBC, Chlorphenesin. -
Be aware suspensions/solutions may not be stable in refrigeration - solutes may fall out of solution at reduced temperature.
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@GeorgeBenson
You need to clearly state your policy. “Very mild” is meaningless as your not looking at irritation/sensitization data.
You don’t like phenoxy because someone might read the label.
What is your policy?