PhilGeis
Forum Replies Created
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Cetyl ethylhexanoate is an ester.
Work with the definitions
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What “oil” do you mean?
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Stability should be conducted in your product package.
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smell and color change - prob should culture. What are pH’s of products?
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To Microformulation’s point, city water typically includes Pseudomonas aeruginosa etc. at some level, typiucally in a biuofilm context. IF you use it, you should heat it 1st -prefer 80C but at least to minimal Pasteurizing levels - ~60C.
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You should check Philippine regs.
60-95% is the typical range - but please be aware the aloe and guava may screw up your efficacy.
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Is this for personal use or to be marketed - and in what country?
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I’ve heard of it but have no experience with this one. Recall it another fake “natural” but is GRAS. Perhaps it’s like polylysine - a cationic.
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ask the MicroCare folks - might be sorbate autooxidation
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Very likely, microbial contamination.
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Microformulation is 100% correct.
I saw no mention of challenge testing even as made, and Gram staining is not a valid means of addressing micro quality any more than eye-balling products in stability. Leucidal is a pretty poor to lousy preservative even if you’re working with irradiated clay (are you?) and will have a lot of challenge in use since most pomades are marketed in open pots
Legally, you must affirm micro safety through the expected product life and use - usually with challenge testing data. Above would appear to have you in noncompliance even with old cosmetic regs. You’ll prob not get a lot of help from experts like Microformulation when you appear to blow off micro safety.
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Pretty sure MIC protocols all use media at +/- neutral pH. MIC is pretty meaningless - inhibition in an overnight culture is a pretty low modest target when the standard is stable kill through 4 weeks.
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Yes - the bugs are the same anywhere and USP is way way to easy to pass. Use ISO 11930 A crtieria.
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As a “disinfectant” - antiseptic, ethanol is an active. How/to what action/efficacy are guava extract, centella extract and aloe vera extract “actives”?
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Yup - I remember those days - and everyone in the room nodding in unison to meaningless jargon.
If you’re in US - wave MoCRA at them, might be a like crucifix to a vampire.
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Think this shows priority - and not for quality.
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Thanks I too look forward to anyone’s experience.
Don’t get too excited by the supplier’s article.
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These are effectively the same test in execution with 51 crtieria being less stringent. As established passing through stability, it would be seen as justifying marketing.
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Dowicil wasn’t bad - P&G used it in their product as well.
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Perhaps like quats - destabilizes membranes and transport. Quats disinfectant work great in testing, pseudomonads can contaminate in practice.
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and that may be contamination as well
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MIC - it’s pretty meaningless.
For challemge - USP/EP/BP/ISO/ASTM all have the same bugs (these were 1st isolated 60 + years ago - the staph almost a century old) and are more of less identical but for acceptance criteria. ISO is ok but it offers the wriggle room of A amd B, and non of these demands the bugs actually be eliminated at any time point. In real life with real contaminants - bugs that hang around learn to grow.
.Major companies that use this general challenge protocol demand even more - usually no detects at 7 days. They typically also add bugs that can or have contaminate esp, Burkholderia cepacia and a few others.
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It’s just inhibition (not kill) vs the wimpy lab strains and only for 12-24 hours..
Efficacy in a formula - and experience wiith other formulas.
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Can you offer any more detail? This sounds like a lot of BS for an officious assessor.