PhilGeis
Forum Replies Created
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Sunscreen development should pursue efficacy rather than minimalist concept. Variations in usage , stability, manufacturing will have a “just enough” formula leaving some users with insufficient protection.
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If “binding” to reducing biological activity - reducing exposure and irritation - why add?
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You’ve a poorly-preserved turning pink. What are micro data?
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Doubt you’ll find a risk assessment and it’s a good bet youtubers never bothered.
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https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/microneedling-devices
fda.gov
The FDA has reviewed and legally authorized specific microneedling products as medical devices for use in specific areas of the body.
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Choice of supplier is sometimes forced by volume you want as some will not sell small volumes. Suggest you also consider Arxada. These guys have consolidate some of the older supplier houses - Dow MC, Lonza etc. and rather than just repackaging combinations are developing preservatives - real stuff, not natural eye of newt toe of frog BS.. Their phenoxy may not be special but their profits are investments.
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On what data are you claiming biodegradability?
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“Safe”?
pH - not at issue. Skin has no pH per se but techniques that propose to measure find it effectively buffered.
Fatty acids in soap - short chain are more biologically active - C12 may be more irritating on skin than longer chain.
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To your questions - cleaning what material and neutralization/eliminating what odor?
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That is a poor preservative system and a higher risk population is exposed. What is pH and packaging?
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That is a pretty weak preservative system - not much Gram neg protection.
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Was this changed supported by challenge by data?
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Agree, the ascorbic acid reaction to benzene is not a concern in this context. Might have problems with some clays, but I’d not worry much.
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Cosmetic claims are generally hype so minimalist approaches(fairy dust addition) are common. If I understand, you ask why not use a small amount of the sunscreens as it could have some effect and prob can’t hurt. Maybe - but you can’t do this in the US. It shows intent to achieve a drug effect thatbwould require approval by NDA or compliance to the relevant monoograph.
The oxides are not inert - simply reflecting light energy. The absorb light energy to form free radicals that might provoked irritation.
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Can you offer a risk assessment beyond no reports of issues. MoCRA alone will require a data based risk assessment that folks should already have.
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Another poor preservative system. What are the micro data?
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Where are you with preservation?
As stated above phenoxyethanol is NOT coconut derived.
Benzyl alcohol and DHA is a poor preservative system and you’d be better off with Benzoic than Sorbic acid.
Leucidal is a WASTE.
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If using an alcohol - suggest phenoxyethyl rather than phenylethyl. Need to know pH before trying organic acid.
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Excellent article. I’ll add a chelator like EDTA you should be using to facilitate preservation should also be constraining potential production of benzene and it’s doubtful your pH is low enough to drive the reaction <3.
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Be aware - the product preservative will not have any efficacy in dilution.
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you do not need the plus.
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Agree - MIT/CMIT prob not appropriate. Can you describe packaging, process and anticipated consumer use?
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What is your country - regulatory climate? Methylisothiazolinone effectively banned in EU.