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can serum be saved?
Hi, i would like to ask an opinoin if there is any chance separated water gel serum be saved or rework?
Anyone had deal with this kind of problem? thank you
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8 Replies
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Depends on the reason.
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we suspected it during processing. maybe not enough time for thickener and active bind together. not sure if it right
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It might be possible but it also depends on what ingredients are in the formula.
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there are only water soluble active, they only thing i susppected is either the process or do you think fragrance can cause instability? we put 0.1% only. we do have carbomer as thickener and EGMS as pearlizer/co emulsifier.
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Sure, the fragrance can cause separation. Also, if you have high electrolyte levels that can break the carbomer structure and cause separation.
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ohh thank you, btw is glycol stearate can cause instability? as far as i know, it usually can act as co emulsifier.
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There are many factors and it comes down to Process Engineering.
Is the Formula stable to begin with as demonstrated through stability testing? In an effective organization, this would be a yes.
What incipients may need to be added to fix the product, how does your QA Program address this change, and will it make your labeling inaccurate? Anecdotally I once saw someone add an unmeasured and unclaimed amount of Sepigel 305 (laughingly called the “batchmasters friend”) into a batch which I then refused to clear from QA/QC Hold.
Multiple other issues you can identify that may be process-related or plant specific.
In the end, be conservative. In the end, you need to weigh any issues of noncompliance over any fungible losses.
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we are trying to figure out the root of the problem. is it really the formulation unstable or processing. cause when we did in small batches in lab, apparently, no issue.
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