Home Cosmetic Science Talk Formulating Will gluconolactone hydrolyze on skin as good as in water?

  • Will gluconolactone hydrolyze on skin as good as in water?

    Posted by zetein on April 30, 2024 at 9:00 pm

    Gluconolactone will hydrolyze in water and acts as alpha-hydroxy acid, and offers skin benefits.

    If I homogenize gluconolactone in an (almost) anhydrous liquid like glycerin and propylene glycol, theoretically, will it hydrolysis after applied onto skin and effectively exfoliates?

    Out of fun I tried to pour gluconolactone powder into glycerin, and it did end up with a clear liquid, though it took quite a long time (months), and I’m not sure if any chemical reaction, say, esterfying, happened. The solution tasted just a little bit sour, so I guess there’s very little gluconic acid in it.

    I find a chart below. Can I use this to determine that gluconolactone will be maximally hydrolyzed after 100 minutes in water? If I put unhydrolyzed gluconolactone on skin, will it hydrolyze the same, and thus gives me “slow-release” “gentler” AHA benefits?

    zetein replied 2 weeks, 4 days ago 1 Member · 0 Replies
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