PhilGeis
Forum Replies Created
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“liquid germall” - as in Germall Plus?
see this video - https://www.youtube.com/watch?v=UPjoOQDyQMo
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I’d not get too carried away with pKa - your formula may impact. Suggest 2500-3000 Na benzoate at favorable pH. Do not think sorbate/DHA buys anything more and brings in more question of stability.
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Why? A pH limitation?
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Citric lactic - suppose can try either. I’m just a preservative guy.
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Think that would be better
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Can you lower the pH enough to accomodate an organic acid?
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That combination is not esp. good vs. fungi - or much else beyond phenoxy by itself.
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I’ve heard the same for ZPT - data did not support. What are the data for piroctone?
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Familiar with Piroctone olamine as a dandruff active - it’s another hydroxamate chelator. Not much experience as preservative - efficacy, stability, formula interactions, water quality- cations
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Pools as simple water solution without the cosmetic poo and goo and biguanides are substantive - cosmetic packaging offers much more surface area to a small volume of product.
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Graillotion is as always quite correct.
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Not sur the max - but at least
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Just sales literature
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Prob not much difference but use the 1st - there are some data for EHG as booster. I’d drop the phenoxy to 0.5%.
I don’t know why anyone would bother with Phenethyl alcohol as a preservative when they can use phenoxy.
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Per Graillotion’s comment- what’s pH?
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As always chemicalmatt is spot on. BKZ is so lame that Pseudomonas grows in the stuff
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What is the cosmetic effect of these extracts? Do you have an in vitro assay?
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Here is the overall history of this and related monographs https://www.fda.gov/drugs/historical-status-otc-rulemakings/rulemaking-history-otc-topical-antimicrobial-drug-products#Consumer_Antiseptic.
The FR citation you offered addresses only one of these topical antimicrobial product monographs, specifically
This document covers only OTC
consumer antiseptic rubs that are
intended for use without water. This
document does not cover consumer
antiseptic washes (78 FR 76444, 81 FR
61106); healthcare antiseptics (80 FR
25166, 82 FR 60474); antiseptics
identified as ‘‘first aid antiseptics’’ in
the 1991 First Aid tentative final
monograph (TFM) (56 FR 33644); or
antiseptics used by the food industry.The FR offers a CDER contact person - Anita Kumar, Center for Drug
Evaluation and Research, Food and
Drug Administration, 10903 New
Hampshire Ave., Bldg. 22, Rm. 5445,
Silver Spring, MD 20993–0002, 301–
796–1032. You’ve best advised to contact Ms. Kumar. -
Not MIT - sensitization problems.
If phenoxy you’ll still need a counterpart to the “+” of Germall +.
Any more info on your growthj?
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Oneka is silly. I’m more familiar with PHMB but Biguanides are good for swimming pools, poor in cosmetics.
Phenoxy/EHG/chelator/Benzoate at that pH should be ok.
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Right - but still think “Jaws” theme would have been more catchy
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for example - https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-2494.1988.tb00582.x
and
https://pubs.acs.org/doi/pdf/10.1021/jf60232a072
Nothing is perfect - suggest use what works well in as many preservative applications as possible
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Thanks. Schwartz is an old pal from P&G so I trust the report.
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In theory with Phenoxy/EHG - you need to address yeast/mold and to a lesser extent Gram +.