PhilGeis
Forum Replies Created
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Amen Microformulation!! Recall an instance when poor process design had the preservative precipitate - filtration of “particles” left it unpreserved with predictably contaminated.
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Ethanol is your antiseptic active so 60% or greater. Very Very unlikely you’ll be successful with foaming.
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Curious re definition of sensitive. SLS innovation and success last century was for the resolution of problems with true-soap based products and hard water.
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Always use multiple preservatives.
1) no single preservative has true broad spectrum efficacy
2) it’s harder for a contaminant to adapt to multiple preservatives vs a single compound
Phenoxy is prob best 0.5%. ECT is over formulated
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Thanks. Pretty casual “science” published in a second rate journal. I’d not put too much significance to normal product use/benefit. They tested a product with 30% EMU oil, not the ingredients or vitamins; control/placebo was not defined; 11 subjects split between test and placebo in unidentified numbers; product application via pad was uncontrolled; technical benefits reported vs visual expression,; questionable interpretation (Fig 3 - claimed benefit when errors bars clearly overlapped).
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Sorry - 10% Emu oil.
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With some surfactants, the effective pKa of benzoate is increased making it effective at higher pH.
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the curse of Dabre - the partron saint of garbage science.
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Benzyl alcohol, Kathon and EDTA is a good combination.
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Unless you can are willing to chase a benefit in clinicals, cut it down to minimal levels.
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Imagine my surprise!! Ricky Mountain product development never got back with info requested.
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Hard to see how they “sterilize” and maintain as sterile packaging and raw materials and how thyey consider Aw in context of an emulsion.
Asked for validation through consumer use - they forward to their product development.
Let’s see.
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here’s what they said, it’s BS
Products can be made with zero preservatives (oat lotion) adhering to the following conditions:
Use 100% sterile raw materials
Use 100% sterile packaging materials
Follow strict GMP from start to end, as listed below.
Design the product as very low water-activity
Maintain the pH in the 4-6 range
Use raw materials which act as pseudo-preservatives.
Minimize human (user contamination).
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Sure seems risky. i asked for their justification Let’s see what they say.
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Can you identify the specific product/brand?
Is there anything unique about the package?
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I’d confirm Biotin is responsible, and if so, reduce it to 0.01%
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Disinfectant?
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correction …… with the right challenge test.
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One can see the impact in challenge test results - with the right challenge test resukts.
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What do you think is caffeine’s impact on those conditions?
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0.7 prevents growth, does not kill. For emulsions Aw may not matter.
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I have some insight re. this - the active is not the only “tricky” element.
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Boss is frustrated. Unless he funded and named someone to follow Chinese reg’s - it’s on him.
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PLEASE - read this stuff carefully before accepting it’s BS.
The guava article is a classic example of garbage science published in a 3rd rate journal. Their protocol couldn’t tell the diff between Pov-Iodine and saline or likely anything, much less show something about guava extract. Everthing was the statistically the same so they concluded an “implied”a benefit for guava.
The other links are to verbage.