[Pharma]

You didn’t actually buy that thing, did you? 😮

There’s glyceryl linoleate in it… at least they can claim to use a penetration enhancer (without proper testing, who knows if it’s the right one for CBD).

Even if, 250 mg CBD in the full 50 g pot isn’t much and you’d have to re-order every few applications the latest.

[Pharma]

Since we’re already drifting OT: why not go with ammonium nitrate instead and, quite literally, get more bang for your buck :smiley: .

Seriously, that pink salt might actually be manganese sulfate monohydrate which has a solubility just slightly above the 6 lbs per gallon??

BTW heating can speed up dissolution but, in case of sodium chloride, won’t increase solubility much (other salts are soluble at considerably higher % in hot water and will crystallise out upon cooling).

[Pharma]

@Perry Good point! Encapsulations for pharmaceutical use fall often in one of the following categories: oral drugs, need to be stored in the fridge/freezer, are mostly experimental/proof of principle, or are liposomes and derivatives. They’re also often used more or less plain with just a few other ingredients from a fairly short list.

What’s the point in using ascorbic acid packed liposomes when you can load an optimistical 10-50% but can’t afford adding more than 5% liposomes to your cream?

[Pharma]

You probably could do it with cheap equipment made in China and some dummy guidelines found on the internet… however, the point where you will fail is determining whether or not it actually worked and if it did, how much actives you’ve actually incorporated. The best theoretical approach is useless when you don’t have any quality control of your practical application.

[Pharma]

How did you measure pH? pH paper won’t work properly and cheap electrodes may not be linear below pH 1-2. Also, concentrated acid solutions will often not match the calculated/predicted value.

Feel free to calculate it yourself, HERE‘s how. Simply calculate Ka for lactic acid and the used concentration in molar and use these values instead.

[Pharma]

You mean Cetiol Ultimate? I think it’s utter nonsense to add that to a shampoo, why would you?

Yes, it would affect foaming quality and no, I don’t think you’d profit from any feel enhancement (if you were to feel anything other than reduced foaming efficacy). It’s not a full silicone oil substitute and certainly not in shampoos.

For what it’s worth: No, I did not try it in a shampoo because it simply doesn’t make any sense.

[Pharma]

Graillotion said:

Pharma 

BTW at this late time of the day it’s ‘guete Abe’ .

Actually….depends on who’s timetable we used…. As you know….we are exactly opposites….hehehe….12 hours apart.

Just trying to boost not only preservation but also your vocabulary in a subtile way… guess it didn’t work, or did it?

[Pharma]

You mention oil several times… what oil? How much of each ingredient?

Did you try a silicone emulsifier?

[Pharma]

LoL! You’re taking Swiss German classes, nice :smiley: !

BTW at this late time of the day it’s ‘guete Abe’ .

[Pharma]

Pink salt? You mean that stuff also called Himalaya salt which it’s most often mined (or forged) in the Pakistan privince of Punjab about 2000 kilometres away from the Himalayas?

[Pharma]

Silicon ois, volatile or not, are usually so lipophilic that they don’t even dissolve oils and hence sebum properly. C5 is most of all a volatile inert filler whilst C11 (linear as well as ‘iso’) and the like will mix with oils and sebum at any proportion rendering these more liquid, hence the perceived emolliency.

An emollient is, as far as I can tell, anything which isn’t water and isn’t doing anything else (e.g. emulsifying, preserving, colouring) in a formulation 😉 .

[Pharma]

Don’t know for sure but I guess that the particles are so fine (and certainly not as ‘edgy’ as diatomaceous earth) that you’d need to rub till your arms hurt in order to get noticeable abrasion/exfoliation… or you apply the cream with a sandblaster, that’ll do a nice job removing all wrikles and age spots and skin and connective tissue and eyeballs… :smiley: .

[Pharma]

‘Chemicals’ which kill animals are considered drugs and/or pesticides in the EU. However, silicon oils and, less effectively, plant oils will kill arthropodes and are, depending on claims, not neccessarily considered pharmaceuticals.

Mind, though, oils are much more effective against ‘stationary’ insects such as lice and will not keep ticks (which are mites, not insects) from stinging (the biologically proper term when they bore their proboscis into the victims skin). The slow death oils inflict on ‘settled in’ ticks will not only be too late to prevent transmission of certain diseases such as TBE but can actually increase speed and performance of bacterial transmission due to regurgitation/vomiting during death struggle.

Free lauric acid as can be found in unrefined coconut oil is a tick deterrent… too bad that you’d need to cover a dog in so much coconut oil that it would look like freshly dunked in a deep fryer (guess only few people would appreciate that… sorry for the tasteless joke…).

Apart from that: Good insecticides are not applied as shampoo or conditioner for so many reasons. Just see a vet if your pet has parasites .

[Pharma]

It ‘attracts’ just water. Subsequently, some water soluble molecules will then diffuse into the newly hydrated skin layers.

[Pharma]

Graillotion said:

…
I am typically using GLDA as my chelate…but also have sodium phytate on hand…. so could switch if need be.
…

Do not use phytate with silver (or any other metals). Phytate forms insoluble salts with most metals (in case of monovalent ones not chelates but that doesn’t change much).

[Pharma]

The problem might be rose oxide, the main flavour component in essential rose oil. It has a very low scent threshold (one can already smell a ppb) coupled with it’s low concentration = it may for example evaporate to a degree even if the bottle seems hermetically sealed.

Store expensive EOs in the freezer.

[Pharma]

I tried Cetiol Ultimate neat and it’s a bit like a solvent (wait-a-minute! It IS a solvent :smiley: ). What I’m trying to say is that it removed all sebum from my skin and left the area where I’ve tried it white as if I had used acetone or white spirit. I suppose that this washing out effect may be corrected by adding emollients and oils.

Does it feel like C5? Nope, not for me. The main things in common a user might notice is volatility and fast spreading, the rest is just not close enough.

[Pharma]

Question: The webinar mentions trace elements. Your homepage mentiones microelements instead and that term is somewhat ambiguous; it may also refer to micronutrients which includes not just essential trace elements but also vitamins, essential amino acids, certain fatty acids…

Most of these aren’t volatile and in case of trace elements, these are minerals (mostly heavy metals) which can not be destroyed by any reaction condition except nuclear fusion and the like… The thing about most trace elements as well as micronutrients alike is that they usually don’t evaporate at noteworthy levels unless you start heating to hundreds of degrees centigrade, hence the use of distillation to obtain pure water. How comes that your low temperature evaporation ‘extracts’ trace elements at near quantitative levels?

Do you work at reduced or ambient pressure? In the latter case, theory has it that a good part of the volatiles (such as many terpenes and those ‘liquid biologically active substances’ as you call them) will not be extracted/distilled. My conclusion is (I have to speculate here because the technology you describe & draw as rudimentary comic is kept very vague) that you use maceration/self-digestion possibly followed by juicing and/or filtration even though the mention of a 30-35°C air flow implies some sort of distillation. The resulting ‘juice’ would then contain a good portion of trace elements and probably a sufficient amount of polyphenolic constituents (mostly tannins) to render the soup self-preserving.

Do you have and data on precise composition and active constituents? Do you standardise your extvolate? If so, to what? Do you have MIC or MBC data you could share?

With all those scam products marketed as natural preservative alternatives out there which actually contain QAC and what not, I’m sceptical beyond my inherent scepticism as a scientist when stumbling across a product like yours.

[Pharma]

Lipophilic glycols are oil soluble/miscible. Pentylene glycol is just in between water and oil soluble. Shorter chain ones, like the others you mentioned, are only alcohol andwater soluble. These may be incorporated using emulsifiers/co-emulsifiers.

This Ordinary product likely contains pentylene glycol as part of SymSitive (+ 4-t-butylcyclohexanol) and therefore, the amount should be in the low % range which is likely low enough for full dissolution in the oil base.

[Pharma]

You’ll have a hard time finding dipropylene glycol because it’s an ether and ethers are quite rare in nature.

Propylene glycol can be prepared (synthetically using green chemistry) from renewable feedstock such as lactic acid but to my knowledge isn’t (yet) done on a commercial scale probably because production of propanediol (above mentioned Zemea) is more economical and ‘chemistry-free’.

[Pharma]

As a rule of thumbs, traditional anionic surfactants often have HLB values above 15 (sulfates even above 20 and di-anionic ones above 25).

However, using a modified method according to Davies, I came up with ~7 for sodium cocoyl isethionate and sodium lauroyl methyl isethionate (which is obviously utter nonsense) and ~13 for caprylic/capric and lauryl glucosides. However, calculated HLB refer to pure compounds and may deviate considerably from measured values of cosmetic grades. Also, HLB is often not applicable to non-traditional (PEG-based and SLS derivatives) emulsifiers.

[Pharma]

Define ‘water retention within formulae’.

HLB is a system describing the hydrophilic vs lipophilic portions of certain amphiphilic molecules and helps determining optimal formation of ‘stable’ cubic phases. This has nothing to do with water retention. If you want to retain water within a product, add humectants (hygroscopic substances).

[Pharma]

Maybe, maybe not. Some microbes aren’t visible at way higher amounts, don’t produce neither smell nor gas… just think about yoghurt. You wouldn’t know it’s spoiled milk if you didn’t know what yoghurt actually is.

[Pharma]

Abdullah said:

…
Does one colony in test means one microb?

Simply said, yes.

[Pharma]

Dermofeel PA-3 is sodium phytate in hydroalcoholic solution… what should that change?