Home Cosmetic Science Talk Formulating Advanced Questions Chelating agent as preservative booster. How and against which organisms

  • Chelating agent as preservative booster. How and against which organisms

    Posted by Abdullah on December 28, 2021 at 3:40 pm

    Against which organisms does chelating agents boost preservative effectiveness?
    And by which mechanism?

    One that i know is against aeruginosa by chelating calcium from its biofilm so preservative can penetrate better and work better.

    What more.

    Pharma replied 2 years, 4 months ago 4 Members · 9 Replies
  • 9 Replies
  • PhilGeis

    Member
    December 28, 2021 at 6:04 pm

    That is certianly one.  Also offers competition for other trace elements - Fe, Mg, CU.

  • Abdullah

    Member
    December 29, 2021 at 1:39 am

    @PhilGeis thanks 
    Will this mechanism effect all microorganisms or some of them

  • Graillotion

    Member
    December 29, 2021 at 2:38 am

    PhilGeis said:

    That is certianly one.  Also offers competition for other trace elements - Fe, Mg, CU.

    Speaking of the metals….how about Silver?  Before you start swearing… I am using silver citrate at a low rate in a deo product, NOT as a preservative.

    So I have read slightly conflicting thoughts amongst Phd’s on silver citrate in relationship to chelation.  So I was curious if you could weigh in on the topic.  One respected Phd basically said…without giving any details…. Silver Citrate and chelation don’t mix.  The other one….which I consider one of the most brilliant minds on the planet said this: Silver ions carry a single positive charge and, according to the HSAB system, are ‘soft acids’ which have a high preference for ‘soft bases’ such as thiols. Simply put, silver is a …. poor ligand for most chelates and will not interfere with GLDA or EDTA. These chelates may bind to the surface of colloidal silver particles but, unlike zinc, the effect isn’t strong enough to neutralise anything.

    I am typically using GLDA as my chelate…but also have sodium phytate on hand…. so could switch if need be.

    Aloha @PhilGeis  

  • PhilGeis

    Member
    December 29, 2021 at 7:56 am

    Abdullah said:

    @PhilGeis thanks 
    Will this mechanism effect all microorganisms or some of them

    Not much info. Microbial dynamics can be different.  EDTA by itself is not a preservative.

  • Pharma

    Member
    January 3, 2022 at 6:51 pm


    I am typically using GLDA as my chelate…but also have sodium phytate on hand…. so could switch if need be.

    Do not use phytate with silver (or any other metals). Phytate forms insoluble salts with most metals (in case of monovalent ones not chelates but that doesn’t change much).

  • Graillotion

    Member
    January 3, 2022 at 6:57 pm

    Pharma said:


    I am typically using GLDA as my chelate…but also have sodium phytate on hand…. so could switch if need be.

    Do not use phytate with silver (or any other metals). Phytate forms insoluble salts with most metals (in case of monovalent ones not chelates but that doesn’t change much).

    Guete Morge

    Thank you for your brilliance….you input is of immeasurable value.

    Guet, merci

  • Pharma

    Member
    January 3, 2022 at 8:46 pm
    LoL! You’re taking Swiss German classes, nice :smiley: !
    BTW at this late time of the day it’s ‘guete Abe’ ;) .
  • Graillotion

    Member
    January 4, 2022 at 1:32 am

    BTW at this late time of the day it’s ‘guete Abe’ ;) .

    Actually….depends on who’s timetable we used…. As you know….we are exactly opposites….hehehe….12 hours apart.

  • Pharma

    Member
    January 4, 2022 at 8:43 am

    BTW at this late time of the day it’s ‘guete Abe’ ;) .

    Actually….depends on who’s timetable we used…. As you know….we are exactly opposites….hehehe….12 hours apart.

    Just trying to boost not only preservation but also your vocabulary in a subtile way… guess it didn’t work, or did it?

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