Gunther
Forum Replies Created
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Cst4Ms4Tmps4 said:
On a different note, the European Commission Cosmetic ingredient database (CoSing) states that Triethanolamine of any kinds, its maximum concentration is 2.5% for leave-on products.
Interesting.
They even seem to restrict products where TEA has reacted with an acid
like TEA-carbomer or TEA-cocoate. -
bahey said:what’s happened if i raised pq7 to higher ratios like 2-4 % ?
Nitesh Rajput advises to use 2-5% (as-supplied)
https://chemistscorner.com/what-is-polyquaternium/ This study used 1% active PQ-7
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000400013It looks like anionics hinder PQs deposition
Liquid Detergents
2nd edition
edited by Kuo-Yann LaiSo I wonder if most eveyone is getting mediocre results, just because they are using too little PQ-7?
1% of a 10% solution is just 0.1% active PQ7. -
They work fine.
Remember you never heat anything in the beaker directly. Always use a water bath.
https://en.wikipedia.org/wiki/Bain-marie
https://en.wikipedia.org/wiki/Heated_bath
https://en.wikipedia.org/wiki/Laboratory_water_bathIf you must warm something above water boiling point, or if you’re working with an anhydrous product, use oil instead of water to prevent water vapor from contaminating the formulation.
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While some studies suggest that creating works for aged skin,
as far as I know, creatine slowly degrades in water solution.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080578/
https://www.ncbi.nlm.nih.gov/pubmed/19635041
https://www.academia.edu/6026552/Effect_of_water_activity_and_temperature_on_the_stability_of_creatine_during_storage_Effect_of_water_activity_on_creatine_stabilityA creatine salt like Creatine HCl or Creatine citrate (which you can make by reacting creatine monohydrate with dilute HCl or citric acid yourself), might be a bit more resistant to degradation.
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Interesting, thanks a lot for the answers.
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They are dishonest too
They “forgot”to mention that their cleanser contains NaOH or something alkaline enough to saponify oils
INGREDIENTS:Aloe barbadensis leaf juice*, water*, watermelon seed oil*, grapeseed oil*, castor oil*, calendula oil*, walnut oil*, Camellia Japonica oil*, coco betaine*, cocaminodopropylamine oxide*, phenyoxyethanol, sorbic acid*, caprylyl glycol*
https://www.oumere.com/pages/ingredients-oil-dissolution-theorySoap?
It’s funny because they disregard soap because of it’s high pH7. Foaming agents in cleansers
Foaming cleansers are destructive to the skin because they weaken the very defense that protects skin from bacteria: it’s pH. Foaming cleansers are alkaline, and take your skin from a healthy, bacteria-fighting acidity, to a weak alkaline state that is vulnerable to bacteria. Those with bacterial acne and other skin ailments have a skin whose pH is too high, which breaks skin cells down. I always tell people, cleansing your skin will not cure acne, but using the wrong cleanser can create acne (or make existing acne worse).
https://www.oumere.com/blogs/news/your-natural-non-toxic-skin-care-is-extremely-cytotoxic
Aloe barbadensis (Aloe vera) leaf juice?
They don’t seem to realize that the International Agency for Research on Cancer IARC lists Aloe Vera whole leaf extract as a Class 2B possible carcinogen
https://monographs.iarc.fr/list-of-classifications-volumes/
Group 2B: The agent is possibly carcinogenic to humans.
There is limited evidence of carcinogenicity in humans and less than sufficient evidence in experimental animals. It may also be used if there is inadequate evidence in humans but sufficient evidence in experimental animals. Occasionally, an agent (or mixture) may be placed in group 2B if there is inadequate evidence in humans and less than sufficient evidence in experimental animals but there is supporting evidence of carcinogenicity from mechanistic and other relevant data. An agent or a mixture may also be classified in this category solely on the basis of strong evidence of carcinogenicity from mechanistic and other relevant data
https://monographs.iarc.fr/wp-content/uploads/2018/06/CurrentPreamble.pdf
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pH 10 is just too high. It will surely irritate and even strip off the skin.
Lower NaOH or increase LABSA to get a pH that’s about neutral.
Pour the last 5% of the NaOH slowly, checking its pH frequently.
You can even get a slightly acidic pH 5-6 sulfonates reverting back to free LABSA.
Stay away from highly acidic pH levels < 3 from unneutralized LABSA too.You just don’t just add salt.
You need to determine the proper amount of salt, depending on the viscosity you want.
Read about doing a salt curve.There’s no preservative in the formula.
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All tanks should have some volume markings, in order to fill them up to the desired volume as to compensate for evaporation losses.
That’s why most formulas mention q.s. to 100%In large stainless steel tanks, height and diameter are usually measured, do some math, and weld or solder some protuding marks.
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ngarayeva001 said:Inspired by this conversation I made my own version of “heat protectant” yesterday:
Phase INCI % W Aqua 67.8% W Disodium EDTA 0.5% W PVP 0.5% W VP/VA copolymer 1.0% W Amodimethicone (emulsion) 1.0% W Propylene Glycol 5.0% W Polyquaternium 7 0.5% O Cetyl Alcohol 2.0% O Ceteareth 25 3.0% O IPM 3.0% O Behetrimonium Chloride 4.0% O Dimethicone (viscosity 1000) 5.0% Cool down Amodimethicone 1.0% Cool down Cetrimonium Chloride (30%) 2.0% Cool down Germaben II 0.7% Cool down Cyclomethicone 3.0% Cool down Citric acid qs to pH 4.5 It might not provide any real heat protection but it is a very light and nice styling product to be used with flat iron (my hair look amazing today yay!). It’s a low viscosity emulsion easy to apply. I will attempt to do some stability testing and share here if there are any issues.
Interesting.
However, can propylene glycol catch fire?
Flat irons temps do get to its flash point:
https://monumentchemical.com/uploads/files/TDS/PG%20-%20TDS.pdfAlso, the study says that PVP provides no heat protection, but VP/VA polymers do.
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You don’t have any proper emulsifier there so water and oil phases will quickly separate.
I doubt 4% TEA stearate can emulsify 5% olive oil and 2% cetyl alcohol. -
This is as useful a response as it can get
FDA Regulations clearly state that you’d need a licensed pharmacist.
So you’d better find one and ask him or her.
Don’t ask in an Internet board (that’s focused on cosmetics, not pharma, by the way) -
First, make sure you’re not unknowingly infringing any patent
hopefully, you can find an expired patent that lists the typical composition and manufacturing methods.
Google patents or freepatentsonline.com can help. -
Do you do microbiological or stability testing?
If you do, then you’d need some incubators and autoclaves (some of them look pretty sleek), but you’d better keep the microbiology lab in a separate room.Some bottletop dispensers look neat and speed up measuring liquids.
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This is a pharmaceutical product, even if it were approved to be sold OTC,
this is something only a pharmaceutical chemist should formulate, not an amateur. -
insan said:Need a formulation of charcoal toothpaste.
Please read the board rules
this ain’t a board for free formulas
first you must experiment yourself and only then ask for questions when you get stuck.
And please stop spamming other people threads asking the same thing. -
Does management know about this?
Why are they so interested in improving the way the lab looks, instead of the way it works? This may be a red flag as they might be considering selling the company, or ask for a loan or money from other investors.
Close cabinets and wall tiles or stainless steel sheets may make it look better.
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ngarayeva001 said:https://www.glamourcosmetics.it/gb/gc-btms-plus
Use google translate. This is Italian supplier (small quantities) similar to lotioncrafter and makingcosmetics. They have more interesting things than some US suppliers. Internationall shipping is available (I am not based in Italy myself).I personally perfer this BTMS because I can control the viscosity of the product better with it. It’s 80% active BTMS and just 20% cetyl alcohol. Compare with your BTMS 25, where there is only 25% of active BTMS and 75% of cetyl alcohol.
Should you add add more fatty alcohols to BTMS-50 to increase viscosity?
Or just add more BTMS-50? -
Avirock said:Please anybody tell us the roles of all these products in dishwash
Please get the following information.
Water 86.3%
LABSA 9.4 %
NaOH 1.25%
CDEA 2.7%
EDTA .1%
Sodium chloride .2,%
Water: solvent
LABSA + NaOH: they react to make Sodium alkylbenzene sulfonate, the surfactant
CDEA: Improves foam height and stability
EDTA: Makes the preservative (which ain’t there) work better, improves foaming in hard water.
Sodium chloride: salt, thickens the formulation
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To be able to state a certain SPF figure on the label, expensive testing is needed.
Sunscreens are totally out of reach of small companies and home formulators.1 First you’d need to know how much UV rays can ZnO and TiO2 absorb
As TiO2 is more effective in UVB and ZnO in the UVA range, the combination of these particles assures a broad-band UV protection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781714/Particle size greatly influences UV absoption
However, to solve the cosmetic drawback of these opaque sunscreens, microsized TiO2 and ZnO have been increasingly replaced by TiO2 and ZnO nanoparticles (NPs) (<100 nm). This review focuses on significant effects on the UV attenuation of sunscreens when microsized TiO2 and ZnO particles are replaced by NPs and evaluates physicochemical aspects that affect effectiveness and safety of NP sunscreens. With the use of TiO2 and ZnO NPs, the undesired opaqueness disappears but the required balance between UVA and UVB protection can be altered. Utilization of mixtures of micro- and nanosized ZnO dispersions and nanosized TiO2 particles may improve this situation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781714/https://www.sciencedirect.com/science/article/pii/S13
2 Then you need to know how much of these particles remain on the skin to block UV rays.
3 Then you need to make sure they are safe.
SafetyThe International Agency for Research on Cancer (IARC) has recently classified TiO2 as an IARC group 2B carcinogen, possibly carcinogenic to humans.60,61 The IARC conclusions are based on evidence showing that high concentrations of pigment-grade and ultrafine TiO2 dust cause respiratory tract cancer in rats. The IARC considered the observations as relevant to humans since some biological events that cause lung cancers in the rats appear to be similar to those seen in humans working in a dusty environment.Skin penetration
Although in-vitro animal skin penetration studies mainly report TiO2 and ZnO NP localization within the SC and/or hair follicles, some in-vivo studies have detected the NPs in viable skin layers.85,86 Sadrieh et al, for instance, showed that repeated application of 5% TiO2 (uncoated and coated particles, ~20–500 nm) sunscreen formulations on the skin of Yucatan mini-pigs led to detectable levels of the particles in the dermis.Their in-vitro porcine skin penetration studies revealed no TiO2 NP penetration, but in-vivo experiments with hairless mice resulted after 30 days penetration of 4 and 60 nm particles (5% TiO2 in carbopol 940, triethanolamine and demineralized water) into deeper viable epidermal layers. After another 30 days, the particles were allocated in various tissues such as lung (12–18 μg g−1 Degussa P-25), brain (10–15 μg g−1 Degussa P-25) and spleen (22–30 μg g−1 10 nm particles). It should be noted that the ability of TiO2 particles to cross the blood–brain barrier had been previously published.87
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781714/Just the SPF testing will cost 5 figures itself.
Bottomline don’t even attempt to formulate or sell anything claiming a SPF figure yourself. -
ngarayeva001 said:However I don’t think that emulsion based on PEG-40 HCO will be stable. It’s used for achieving micro-emulsions with low % of oil. Such as solubilizing 0.5% of fragrance in a clear solution.
By the way
What’s a good PEG-40 HCO to fragrance ratio? -
LABSA and SLES are too low
increase to about 15% LABSA and 5% SLES to get proper viscosity
salt needs to be slowly added in 0.25% increments (dissolved in water) until the proper viscosity builds.
Better yet do a salt curve experiment.
Formalin is banned and a proven carcinogen. -
Google LABSA molecular weight, then Google it for NaOH.
That’s roughly the proportion needed, just do some simple math for the amount you’re using.Then you’d need to slowly add the last 0.5% or so while checking pH and adjust with additional NaOH to neutral or just slightly alkaline pH.
Beware of highly acidic or alkaline pH levels as they can harm skin. -
Carbonate has no use in soaps, it is often added for 2 purposes:
1 To make increase the formulation pH. Soap is already too alkaline, so you don’t need it.
2 To work as an abrasive to help with cleaning.
Only undissolved carbonate crystals will work as an abrasive. Sodium carbonate is very soluble, even more than bicarbonate, so you’d need a quite lot of it for abrasiveness, likely destabilizing the formula.
Stick to nonsoluble fine grinded abrasives, if needed.