PhilGeis
Forum Replies Created
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fyi
You are dealing with a sensitive population. Please pay special attention to preservation, testing and manufacturing quality.
https://www.sciencedirect.com/science/article/abs/pii/S019567011100020X -
Sephora policy prohibits use of classic preservatives. They’ve provoked many recalls (search Sephora and recall). Don’t take preservatives systems of products they sell as models
Those are garbage preservative systems, esp. for jar packaging. Humectants at cosmetics levels do not effectively lower water activity to effect preservation level performance. “Self preserving” with ’em is BS.
Hexanediol can be useful at high (%) levels vs Gram negatives, less so vs Gram +’s and limited vs fungi.
EHG is a booster with phenoxyethanol. Beyond that it is not know n to have a significant effect.Do not presume PAO means anything.
Please remember, you guys and Sephora’s suppliers use the classic USP style test. It is validated to nothing - not consumer use and certainly not to manufacturing.
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It’s a household product held to no standard.
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No.
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Natural
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“Defies gravity”
but it was for a hair gel.
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Cdsgames said:Some more info.I am using xylitol at 10% to reduce water activity and SAP at 3%. I dont have a chelator .
What is the Aw of your product?
Suggest you look at labels of competitive brands, esp. from major manufacturers.
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Consumer practice will control safety. Will they rinse out pump? Will pump eventually clog - is the ump robust enough to survive “long time” use? Will the pump soil?
Think you need to run some consumer use studies. -
back to the regulatory point
The intent is evident and documented above - in US this product as a drug.
In addition to the monograph, please comply with appropriate 21cfr 201 regulations from registration to CGMP.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=201 -
thanks!
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suswang8 said:Make sure you are noting whether it is thyme oil or thymol when you read up on this. It is apparently extremely potent, as one company is marketing a disinfectant with 0.051% thymol.
Can you identify the product or company - is it in US?
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In this case, to ensure the product has enough preservative capacity to protect during use.
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One cant presume one way or the other. We rarely have simple solutions.
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Lochhead is a well-recognized hair expert
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PET and an estimate for stability qualification.
Conditioners are applied in and around showers and tubs - water gets in during use. Tap water usually has pseudomonads - esp. aeruginosa.
https://journals.asm.org/doi/abs/10.1128/aem.56.5.1476-1479.1990 -
Different folks publish different numbers - and remember, you have a product not a simple solution.
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Eurofins has many global labs. Maybe one somewhere near you might offer PET. https://www.eurofins.com/contact-us/worldwide-interactive-map/
That % might effective. Question is its stability through consumer use,
Historic - development of synthetic surfactant shampoo - classic parabens/benzoic were not effective and marketed products used formaldehyde, then to formaldehyde releasers and in 80’s to isothiazo9linones.. -
0.98 might be optimal but >.90 and less than .98 is not prohibitive.
Not aware of Aw data for combinations. -
Reliable Aw inhibition of pseudomonads typical of cosmetic contaminants - ~60% glycerol and ~20% NaCl. Neither reliably kills.
Most common is Burkholderia cepacia - Pseudomonas aeruginosa is second but prob somewhat greater health risk. -
“Formalin” is sold at diff concentrations. What is final est. formaldehyde concentration?
Do you have challenge data? -
You need to qualify your systems. Water is the one ingredient whose quality is known only after the product is made.
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Sensationalized garbage from a garbage medium. And they can always find some publicity happy “expert” to wring their hands in horror.
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You’ll need a preservative.
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Potential solubility challenges - OIT, EDTA as acid. Like you - don’t understand APG ppt. Maybe Perry knows.