[Nixeus]

Paprik said:

Hey,

this cream looks alright, not sure why you want to add so many actives?
CoQ10 is already there, HA, B5, Vit E acetate (antioxidant for your skin) …
I mean, if you add 0.025% or even 0.5% (which I think you could, if you were using tretinoin for that long), I think you should be fine, preservation-wise. Not sure about compatibility with other ingredients. You would have to do some testing. 

Sometimes less it more. Or make batches and use some actives in the morning and some at night.

This cream is using Euxyl 9010 as one of the preservation. You could calculate how much you dilute it and top up maybe? 1% limit. 
Not promising it will work tho. 

Good luck! 

PS. Send me some tretinoin  

Thanks I would rather add GHK CU but it’s not cheap
For tretinoine, there is easy and cheap way to get it ( From India, you can buy as cream tube…they ship worldwide…no need of prescription and it’s not fake…it’s legit tret’). If you want raw tret, you can get it easily with alibaba too ( and cheap).

[Nixeus]

Paprik said:

It’s really hard to say. Could you share the cream you will be adding those to? The ingredient list, so we can see what’s inside and what they used as pa reservative. 

Where did you get the tretinoin, if I may ask? I’m almost jealous, haha. 
0.025% seems fine for the starts. 2 - 3 times a week and see how you tolerate it. And SUNSCREEN! Otherwise what’s the point, right?  

Hi Paprik, i posted the picture with all ingredients.

[Nixeus]

Hi,

I used during 2 years tretinoin at 0,025% each day on my face and tret’ is really a godsend for skin ( better glow, less wrinkles). I have some raw tret’ because i have a friend which is pharmacist  

Here is the face cream base :

[Nixeus]

So i could maybe add a little of sodium benzoate or something else ?

[Nixeus]

Hi, i put low dose tretinoine, 0,025%

[Nixeus]

Hi,

It’s a commercial face cream, and i put my susbtances (as raw), it’s totally for personnal use, on my face

[Nixeus]

Haha sorry since i noob i have to learn about. I don’t have any way to test the ph of my cream  

[Nixeus]

Hi, thanks a lot for your input. So….even if i use all these stuff..i shouldn’t have to ajust the Ph, right ? Or maybe avoid to use Taurine?

[Nixeus]

yeah but it’s more convenient to having tret in the minox solution. btw some supplier sold in the past tretinoin in minoxidil…i wonder if they used BHT in it  or other preservative..Which are the amount of BHT to use approximatively ?

[Nixeus]

sad
I have to find way to stabilize it in my freezer first
In addition to adding tretinoin to cream i add in Minoxidil too since it increase minoxidil activity.

[Nixeus]

Pattsi said:

tretinoin cream base is usually thin with minimal occlusion which is good for acne treatment.

In my humble opinion.
tretinoin cream should only be a prescription drug for ance vulgaris not product for cosmetic use. It is used as an adjunctive treatment in fine wrinkled patients under supervision of medical professionals. I myself am not very keen on using it for cosmetics propose it posts too many risks of side-effects and prolonged usage safety is still the issue. Many Derms prescibe it doesn’t mean you should DIY it. But in the end it’s your choice.

I am sure @Pharma ‘s knowledge in this area is far better than mine. 

I found this short pdf
https://providers.amerigroup.com/AGP%20Documents/PHARM_ALL_CosmeticAnti-Aging.pdf

have you considered using retinol or retinaldehyde?

this study is also interesting too.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841824/

Hi,

I don’t know the stability of retinaldehyde. I have to look for. If it’s stable i could use instead of tretinoin since retinaldehyde will convert in retinaldehyde.

Any idea about stability ?

[Nixeus]

Pharma said:

Fresh and freezer sound promising. Best to aliquot it ASAP upon receipt. Say you were to get 10 g, make 9 x 1 g mini-batches you freeze and 1 you further split into ready to use amounts so you’ll have to freeze-thaw max two times.

Light, apart from oxygen, is your worst enemy and that’s why completely light-tight alu tubes are a good choice. Also working quickly and under dimmed light (no sunlight at all) is advisable.

I once did test tretinoin with FT-IR and you can literally watch it degrade. Not like *ZAPP* and gone, but still a scary degradation speed. If you can afford to, store the cream in the fridge.

There’s a bunch of discussions here, if I’m not mistaken, dealing with how to stabilise a tretinoin cream.

BHT alone won’t suffice, use a combo of antioxidants and radical and oxygen scavengers with different modes of action.

Alternatively, the observed absence of ‘effects’ might be a lack of adverse side-effects because your base is better made than the store bought product :smiley: ?

Thanks a lot for your input.

I think my tret is broken because i remember, when i received it, if i smelled it, it stinged the nose due to the acidity of the tretinoin. If now i smell it….it doesn’t sting the nose.

I don’t really understand because i stored in the freezer, no light

[Nixeus]

Hi, why it isn’t easy to make ? And why aluminium ? Isn’t plastic jar /glass jar not enough ? (is stored in a dark place) ?

Yeah, using standard tretinoin cream is possible but since i can get it raw tretinoin, it’s for me a good idea to mix it in my night cream.

That’s why i’m looking for way to stabilize it.

[Nixeus]

Hi, and thanks for the answer.
My tretinoin is a recent batch from a lab and i store it in the freezer, so i “think” this tretinoin is fine.

So if i’m sure my tretinoine is fine, i should try to add some BHT ? Any idea bout the amount to add ? 0.5% ? More ? Less ? I never used this in the past.

[Nixeus]

Because one hair cycle = 3 month