Home Cosmetic Science Talk Formulating Skin Is there a list of substance who need ph adjustment ?

  • Is there a list of substance who need ph adjustment ?

    Posted by Nixeus on May 12, 2021 at 9:30 am

    Hi people,

    I have a “standard” face skin cream and i would like to add some stuff in it : 

    -Ubiquinone (coq10)
    -Taurine
    -Melatonine
    -Niacinamide
    -Tretinoine
    -Caffeine
    -Msm
    -Dhea

    Nevertheless i don’t know if all these substance will too much modify my cream ph.

    I wonder if it exist a list to see what substance could modify the ph of the cream.

    Anyone could give me some inputs ?

    Thanks a lot :)

    paprik replied 2 years, 10 months ago 5 Members · 17 Replies
  • 17 Replies
  • pharma

    Member
    May 12, 2021 at 5:24 pm
    There are pKa tables available online. However, it’s easier to check each ingredient separately since these lists are not exhaustive.
    -Ubiquinone: No and not water soluble
    -Taurine: It’s an inner salt and buffers somewhere between pH 8.5 and 9.5
    -Melatonine: Alkaline. Poor solubility (and poor stability) in water and hence marginal effect on pH
    -Niacinamide: Alkaline. However, I haven’t observed a raise in pH… Dunno why
    -Tretinoine: Theoretically acidic but not water soluble and hence no effect on pH
    -Caffeine: Alkaline. Rather poor water solubility = low impact on pH. Well soluble in hot water or as salt. Depending on the salt, effects on pH and buffering range will differ (same goes in principle for all acids/bases which are only water soluble in salt form).
    -MSM: No
    -DHEA: No
  • Nixeus

    Member
    May 12, 2021 at 6:05 pm

    Hi, thanks a lot for your input. So….even if i use all these stuff..i shouldn’t have to ajust the Ph, right ? Or maybe avoid to use Taurine?

  • pharma

    Member
    May 12, 2021 at 6:06 pm

    Depends ;)

  • Nixeus

    Member
    May 12, 2021 at 6:15 pm

    Haha sorry since i noob i have to learn about. I don’t have any way to test the ph of my cream :( 

  • graillotion

    Member
    May 12, 2021 at 8:20 pm

    I think what he is saying….for many reasons we generally select a goal for the pH of a product.  So the only way to hit your goal…is to test pH (and then adjust).  A pH meter in the US can generally be purchased for around $20.

    If you are the only one to use your products…probably OK…but if you allow others to use….you should know what you are handing out.

    You did not list all your other ingredients….and some of them could possibly be pH sensitive as well.  (Or is this a purchased commercial cream…and you are just tossing in some ‘add-ins’?

  • Nixeus

    Member
    May 12, 2021 at 8:42 pm

    Hi,

    It’s a commercial face cream, and i put my susbtances (as raw), it’s totally for personnal use, on my face :)

  • ngarayeva001

    Member
    May 12, 2021 at 10:25 pm

    How much tretinoin are you going to add, if I may ask?

  • paprik

    Member
    May 12, 2021 at 10:28 pm

    Hi,
    so you’re saying you bought a facial cream from a store and you want to add some ingredients in it? 
    I would not advise that, especially in this quantity. Imagine, the company creates a preservation system that protects the product for 2 - 3 years. But they usually don’t over-preserve it, to keep the potential irritancy low. If you add some of those actives, it’s basically food source for microorganism. And you are diluting the preservative. This will most likely end up in microorganism grow. 

    Hope that makes a bit sense? :) 

  • ngarayeva001

    Member
    May 12, 2021 at 10:33 pm

    @Paprik, totally agree but in this situation I am much more concerned about tretinoin.

  • paprik

    Member
    May 13, 2021 at 12:49 am

    @ngarayeva001, yes, you are right! I didn’t even go thru all the list properly.

    I’m not even sure, where did he get this ingredient. I’m using Retrieve, which is prescription cream, with 0.05% of Tretinoin. 

  • Nixeus

    Member
    May 13, 2021 at 7:21 am

    Hi, i put low dose tretinoine, 0,025%

  • Nixeus

    Member
    May 13, 2021 at 8:00 am

    So i could maybe add a little of sodium benzoate or something else ?

  • paprik

    Member
    May 13, 2021 at 9:04 am

    It’s really hard to say. Could you share the cream you will be adding those to? The ingredient list, so we can see what’s inside and what they used as pa reservative. 

    Where did you get the tretinoin, if I may ask? :) I’m almost jealous, haha. 
    0.025% seems fine for the starts. 2 - 3 times a week and see how you tolerate it. And SUNSCREEN! Otherwise what’s the point, right? :D 

  • Nixeus

    Member
    May 13, 2021 at 9:48 am

    Hi,

    I used during 2 years tretinoin at 0,025% each day on my face and tret’ is really a godsend for skin ( better glow, less wrinkles). I have some raw tret’ because i have a friend which is pharmacist :) 

    Here is the face cream base :

  • Nixeus

    Member
    May 17, 2021 at 8:48 am

    Paprik said:

    It’s really hard to say. Could you share the cream you will be adding those to? The ingredient list, so we can see what’s inside and what they used as pa reservative. 

    Where did you get the tretinoin, if I may ask? :) I’m almost jealous, haha. 
    0.025% seems fine for the starts. 2 - 3 times a week and see how you tolerate it. And SUNSCREEN! Otherwise what’s the point, right? :D 

    Hi Paprik, i posted the picture with all ingredients.

  • paprik

    Member
    May 19, 2021 at 7:14 pm

    Hey,

    this cream looks alright, not sure why you want to add so many actives?
    CoQ10 is already there, HA, B5, Vit E acetate (antioxidant for your skin) …
    I mean, if you add 0.025% or even 0.5% (which I think you could, if you were using tretinoin for that long), I think you should be fine, preservation-wise. Not sure about compatibility with other ingredients. You would have to do some testing. 

    Sometimes less it more. Or make batches and use some actives in the morning and some at night.

    This cream is using Euxyl 9010 as one of the preservation. You could calculate how much you dilute it and top up maybe? 1% limit. 
    Not promising it will work tho. 

    Good luck! 

    PS. Send me some tretinoin :D 

  • Nixeus

    Member
    May 20, 2021 at 9:26 am

    Paprik said:

    Hey,

    this cream looks alright, not sure why you want to add so many actives?
    CoQ10 is already there, HA, B5, Vit E acetate (antioxidant for your skin) …
    I mean, if you add 0.025% or even 0.5% (which I think you could, if you were using tretinoin for that long), I think you should be fine, preservation-wise. Not sure about compatibility with other ingredients. You would have to do some testing. 

    Sometimes less it more. Or make batches and use some actives in the morning and some at night.

    This cream is using Euxyl 9010 as one of the preservation. You could calculate how much you dilute it and top up maybe? 1% limit. 
    Not promising it will work tho. 

    Good luck! 

    PS. Send me some tretinoin :D 

    Thanks :) I would rather add GHK CU but it’s not cheap :D
    For tretinoine, there is easy and cheap way to get it ( From India, you can buy as cream tube…they ship worldwide…no need of prescription and it’s not fake…it’s legit tret’). If you want raw tret, you can get it easily with alibaba too ( and cheap).

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