Microformulation
Forum Replies Created
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MarkBroussard said:Microformulation said:If there was a sub-group on here that was credentialed Chemists where only these members could post, it would be great. I joined this group early on and it was useful for technical advice. Now it is primarily crafters and hobbyists,@Microformulation, if I recall correctly, Perry (and others) did start a companion site that was for professionals only and had a small annual fee. Perhaps @Perry can provide more information on that site.
I certainly would participate.
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If there was a sub-group on here that was credentialed Chemists where only these members could post, it would be great. I joined this group early on and it was useful for technical advice. Now it is primarily crafters and hobbyists,
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@johnb I couldn’t agree more. I lurk a great deal and will weigh-in occasionally when I feel that a teachable moment or a useful thread begins. I however will not weigh-in on the majority due to the exact issues which you so concisely listed.
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DMSO is not generally used in Cosmetics. It is also not as innocuous as many believe.Dimethyl Isosorbide (DMI) is more common.
Or Ethoxydiglycol;
In the end, these are NOT raw materials for a novice. If in fact any real absorption was accomplished to any area other than the uper layers of the skin, it quickly becomes a drug NOT a Cosmetic.In the end, it is highly doubtful that you will get any real absorption of the actives NOR should you. -
VitalikButerin said:Fekher said:@VitalikButerin actually i work in stainless steel tank.
chinese?
No, the missionaries were American. -
There is a pearlized effect with some of the micellar water two part systems when they are mixed. It is due to the solubulities of the two phases, not the ceramides.
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Cosmetics were made but were inferior in quality. That is called “Scientific advancement.” Lets not disregard the last hundred years or so of progress in Chemistry and synthesis.
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Not always. The short answer is that the company should have a process in place to evaluate the cleanliness of the bottles. You should be able to find a sample SOP online.
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No manufacturer is sterile in Cosmetics. Generally, foreign matter should be limited if stored properly (plastic bags and boxes sealed when possible). A visual inspection and a quick spray with 70% IPA should generally do the trick. If you CM is following cGMP (I assume that is BMP), they will have these processes in place.
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Everyone is spot on. It is a minority of Formulators who do Color Cosmetics and it is also a more fiscally demanding endeavor.Many clients will assume that a Color Line with the same base and different pigments are “the same Formulation” and that they will not require additional manufacturing costs. One product with 5 colors is not one manufacturing run. In most cases, it is 5 runs with minimums attached to each run.It is for this reason that many lines will at least initially start with Private Label. That will allow you to work on Sales/Marketing, Brand Management and all the other Business functions that will really make you succeed. Fortunately, it will also allow you to get a realistic Market exposure to Cosmetics. If you ask a Marketer, many novices are as naive with the emotional aspects of the Cosmetic Market. This will give real-life data and actual exposure.However, as mentioned, if you search any number of directories or peruse the advertisements in HAPPI, you will find someone who provides the service. Remember, it is a specialty, so they will charge accordingly.
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Being that he is in California, even dealing with the THC containing (>0.3% Wt/wt THC) would technically make you international drug smugglers!
The DEA sets that threshold for enforcement for interstate transport. -
I was always under the impression that it was due to Hearst owning many acres of Forest Land. He wanted to eliminate the use of hemp in paper for that reason. He was behind the appointment of Anslinger, https://www.massroots.com/learn/the-man-responsible-for-marijuana-prohibition/
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We use 316 all the time in Contract Manufacturing. If you ever shop for Groen Lee Kettles, it is the grade they use. In a Process Engineering class I took, they endorsed 316 grade for all but some of the more exotic products (toothpaste perhaps).You can look and find a stamp that reflects the grade if you look correctly so you can confirm if your vessel is the proper grade.Except for cost and ease of manufacturing of the vessel or final product, 304 grade is inferior.
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@Belassi I look forward to your puns more and more each day…
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I use Math on a daily basis. One of my undergrad courses was actually on Pharmaceutical Calculations. I think this is simply a peek at some of the value a formal education can bring.
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There is no rumor. There is a CBD analog Epidiolex (cannabidiol) [CBD] oral solution approved by the FDA. It is NOT CBD properly. It has been altered slightly through Medicinal Chemistry to increase affinity for the receptors.I can say for sure without citing rumors that the Tobacco Companies are poised to transition to the cannabis and hemp-based CBD Markets and are heavily invested with money and talent. They will likely dominate the market in 4-6 years.
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You really need to consider the proper grade of Stainless Steel. Processing equipment is usually SS 316 grade.
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Moisturization is a Cosmetic claim. If you extrapolated that it treated eczema (and boy howdy, they do), it would become a drug claim.Why are Cosmetics and Supplements different? Simply due to the fact that supplements are regulated by a different act and considered a separate product. They follow the Dietary Supplement Health and Education Act, (the DSEHA) not the Cosmetic Act. Remember this distinction since someday you will wrongly see someone say that they make any claims as long as they cite the DSEHA.“the law says that if a dietary supplement label includes such a claim, it must state in a “disclaimer” that FDA has not evaluated this claim. The disclaimer must also state that this product is not intended to “diagnose, treat, cure or prevent any disease,” because only a drug can legally make such a claim.” https://www.fda.gov/Food/DietarySupplements/UsingDietarySupplements/ucm480069.htmThe LiceMD Pesticide Free is the Dimethicone product and they use careful wording. I have read that study before, but in that case, it was cited to show that dimethicone was less effective than Permethrin in the same time period. Remember, these studies are small and often they are selectively interpreted.In the end, my best advice is to follow the letter of the law, not what “they” are doing. Remember, LiceMD has a Regulatory expert to consult with to mitigate liability.
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@Soexcited Never feel that you have to apologize for not knowing something. This blog is at heart a learning tool and believing that you have learned it all often becomes a barrier to learning. So, don’t apologize for being intellectually honest. If you approach this group with that in mind, you will gain a great deal of knowledge and many of the Professionals will weigh-in.The best way to explain the monograph system is this. First, learn the FDA Definition of a Cosmetic; “FDA defines a cosmetic as a product (excluding pure soap) intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance.”Notice that the definition has a strict “line in the sand”, that being that a “Cosmetic” cannot address a disease state and cannot claim a physiological mechanism of action. These are “drug claims”, not Cosmetic claims. (I know, you can produce examples of lines violating this restriction, they haven’t been caught and I will only be endorsing textbook answers that address 100% compliance).So, what happens when we make a product that has a drug claim? It either becomes an Over the Counter drug or it could even become a prescription product.The FDA has set-up a monograph system for OTC Drugs. (https://chemistscorner.com/a-list-of-cosmetics-that-have-fda-monographs/).For some guidance on the components of a monograph; https://chemistscorner.com/otc-drug-monographs-and-cosmetics-part-2/If you can remember that definition and have an understanding of the difference between a Cosmetic Claim and a Drug Claim, you are already more advanced than many others.Ask questions, question the validity of ideas and not the person and in the end, you will be a great participant in the Forum.
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Small farmers will not be significant in the Market in 4 to 6 years. The bug companies such as Alliance One and Pyxus are making huge investments and they are producing the product to a much higher level of purity.
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That does not authorize it for OTC. In the US, actives must be specifically allowed in the monograph.
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That is not really approved under the OTC monographs nor is it anything I was ever exposed to in Retail Pharmacy. Can you post a link to a US product?
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Dimethicone?