Microformulation
Forum Replies Created
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Pharma said:@Microformulation Just lemme send you a thumb drive; plug it into your left ear, unzip, mount the image, run the exe. file with full admin rights, and install to your left temporal lobe and you’ll know everything there is to know.
It just reminds me of an old mentor. If you asked him a question, inevitably he would respond, “What has your research shown so far?” You could never expect a direct answer, but it really forced you to follow Journals and buy texts.
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Pharma said:drsimranjit_lv said:…Also suggest a good source to understand emulsifiers in detail if anyone is aware.
Maybe THIS or a book?
You mean do my own research?
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It comes in the form of Hydrogenated Vegetable Oil from the supplier. They are not converting it to a saponified soap.The product brings a “soft” feel, emolliency, and lubricity to the syndet bar.We used this in a reformulation of a major brand syndet as it was in the legacy formulation.
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Not likely. Just look at some of the ingredients that purport to have the same “minerals” such as Dead Sea Salts (Caribbean Naturals has one if I recall correctly). https://www.caribnaturalproducts.com/products.htmlLook for an INCI of “Sea Salt.”Lastly, other than a placebo effect, it is unlikely you are delivering any Cosmetic Benefits from the product. What COSMETIC benefits are you trying to deliver?
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DeepTitan said:Thanks. I do have mineral oil. PolyIsoButylene I dont seem to find.
Microformulation wrote:
You are overthinking the transdermal model of delivery. Generally, the actives are incorporated in light mineral oil and polyisobutylene. It depends upon the delivery of an active across a rate-controlling membrane from a higher concentration to a lower concentration. Pharmacokinetics come into play here.You also don’t have a rate-limiting membrane. Also it depends upon concentration gradients and the pharmacokinetics. You wouldn’t just “slap some on.”
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You are overthinking the transdermal model of delivery. Generally, the actives are incorporated in light mineral oil and polyisobutylene. It depends upon the delivery of an active across a rate-controlling membrane from a higher concentration to a lower concentration. Pharmacokinetics come into play here.
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The Spider Web function really adds little to the finished result.As mentioned, the commercial scale-up process for the Formulations can be tricky. We had no issue with the PEG-90M in the lab. However, the manufacturer had to work to get it dispersed in an 800 KG batch.
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The product is going to yellow regardless of what you add eventually. EDTA won’t offset that.Just use a more stable Vitamin C derivative. Cosmetic Science 101.
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That’s an Alban Muller Raw Material and I have never seen it from anyone else.We used it in a project at a client’s request. It was unremarkable and didn’t stand out from any other dry esters.
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I created a product like this back in the early 2000s. Sadly, PEG-90M is needed if you want the best effect. Essential Ingredients even had a starting Formulation. It can be tricky in manufacturing. https://www.happi.com/contents/view_formulary/2009-03-01/spider-web-crme-wax/
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I believe Mercury Creams, while banned, can be purchased over the Internet and also at some outlets catering to customers from other cultures (Asia, Africa, the Middle East). I recall reading a C&T article regarding these products a few years ago.
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You would need to post your Formula. I would wager that there are other raw materials in the Formula that contribute to these properties and it is less likely to be your rheology agent.
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@sciencebae92 You may also want to look at some starting Formulations from Vanderbilt Minerals. They have some Formulations with more readily available ingredients. For example, unless you find a repacker, the Ganex polymers have a 350-pound minimum order quantity.
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@Perry My guess is that they are simply applying creative marketing to use “biosimilar” for products created using yeast and recombinant technology. While creative, it is hardly new as this has been a standard process for at least 20 years now.
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The products I have seen use Ganex polymers. (https://www.chempoint.com/products/ashland/ashland-personal-care-specialties/ganex-copolymers)What works best would be determined at the bench through empirical means. People underestimate the value of that process.
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I think if you need to see their definition of “biosimilar” and assess if it really IS that innovative.You can’t try and equate Cosmetic Regulatory to the manufacture of Legend Drugs. The testing and documentation is significantly more involved. Unless the system fails completely, testing will be mandated.
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If you look at the market, most of these products contain a film former such as the Ganex line (Ashland) or even Polyperfluoromethylisopropyl Ether. Your product may deliver some moisturization, but without a film former (most likely synthetic) you will deliver little if any real barrier protection.
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I didn’t Formulate it but I was at the company at the time. Another Chemist had been approached to make a “spray-on protector” for sunless tanners. That team (I was in a different department) was directed to make a spray on silicone that could be wiped away preventing discoloration of the hands and soles of the feet.The client loved the product and approved it. They did a demonstration. Well, they didn’t keep in mind that silicones have great lubricating properties. They applied the product, the test subject stood up, and immediately their feet went from under them like a pair of rollerskates. They tried 3-4 more times before resting the project.
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We have had great results with Plantapon SF. Use a refatter, Lamesoft PO65 is great.
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Well, for my needs I will stick with UL Prospector. I get all that with the paid version which is a great deal less and it meets our needs.
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At 20,000 a month I’ll stick with UL Prospector.
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@chemicalmatt What is pricing like? I get all that data through paid access to UL Prospector. Of course in a less user-friendly yet acceptable manner.
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https://www.ulprospector.com/documents/1563772.pdf?bs=604&b=195989&st=1&sl=140770822&crit=a2V5d29yZDpbQWVzY3VsdXMgaGlwcG9jYXN0YW51bSBFeHRyYWN0XQ%3d%3d&k=Aesculus|hippocastanum|Extract&r=na&ind=personalcareHere is some more info. I do think I would be cautiously pragmatic when it comes to efficacy.
