MarkBroussard
Forum Replies Created
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Stems cells are just highly purified plant extracts that are manufactured by plant stem cells so they will not have much effect.
Growth Factors are a different case and this is probably what the derms are focusing on.
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Mandelic Acid, Niacinamide, Panthenol in a deodorant?
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Geogard Ultra generally goes into soluton fairly easily. Try adding it first.
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Are those really your legs and feet?
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Graillotion said:MarkBroussard said:@Adamnfineman
Colloidal Oatmeal 1%
Allantoin, Butyrospermum Parkii, (Shea) Butter, Caprylic/Capric, Triglyceride, Ceteth-2, Ceteth-20, Cetearyl Alcohol, Dimethicone, Niacinamide, Panthenol, Phenoxyethanaol, Ethylhexylglycerine, Tetrasodium Glutamate Diacetate, Water
Interesting choice of preservative (9010) for an eczema product, as you have discussed your research in regard to the irritation of many of the preservative systems to compromised skin.
Yes, I am currently working on an Eczema suite with Colloidal Oatmeal. PE9010 was the best tolerated preservative of all that we tried. I told my client at the beginning of the project to go with PE9010 … virtually all of the best selling competitive products were using PE9010, so there had to be a good reason for that. Could have saved a lot of time if my client had listened to me.
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Colloidal Oatmeal 1%
Allantoin, Butyrospermum Parkii, (Shea) Butter, Caprylic/Capric, Triglyceride, Ceteth-2, Ceteth-20, Cetearyl Alcohol, Dimethicone, Niacinamide, Panthenol, Phenoxyethanaol, Ethylhexylglycerine, Tetrasodium Glutamate Diacetate, Water
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In order for SA to be effecive in an acne product, the SA needs to actually penetrate into the hair follicle. That simply is highly unlikely to happen in a cleanser.
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For small quantities http://www.essentialwholesale.com
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The determination of OTC status of a product is a function of:
(1) Using an OTC monograph ingredient in percentage ranges as defined in the monograph
(2) The intended use is that defined in the monograph (for instance: Acne)
(3) This allows you to use the claims language allowed in the monograph (ie: Acne)
In some instances you will need to conduct an assay to determine the stability and concentration of the active in your specifc formula. But, you generally do not have to conduct studies on individuals to prove that your formula is effective in alleviating the targeted condition.
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People with acne will normally use a suite of products, including leave-on products which is where they get the benefit, from the leave-on products, not the cleansers. But, adding SA to a cleanser certainly will not hurt, it just won’t do very much in terms of effectiveness in delivering an active against acne.
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Yes, any cleanser containing 2% SA and making Acne claims under the FDA monograph would be an OTC. That is primarily for marketing purposes so you can market it as an Acne OTC product.
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The average contact time of a surfactant-based face wash is 20 seconds prior to rinsing. Unless the active has an impact within that 20 second time frame, it generally will not have much of an effect. Placebo effect.
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Yes, just heat the oils up and the SA will go right into solution and generally will be stable with no precipitation.
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Then try changing emulsifiers
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Dtdang said:@MarkBroussard, Good morning!
I am looking for L-arginine to replace NaOH. But, I could not find it in the market. Do you know where can I buy it? -
You have to add quite of bit of it, but it will indeed increase the pH.
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Cut down on the Shea Butter to 1.5%.
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I normally prefer to use L-Arginine, but the two are interchangeable.
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Molecular weight is only one factor that determines if a particular ingredient can penetrate the SC. The super low molecular weight HA does indeed penetrate with the optimal being 200 kDa for HA.
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@sugarcanebeauty4985
You can greatly simply things by using Bakuchiol and Retinol, both of which are oil soluble as opposed to these extracts from Making Cosmetics.
Lecithin generally will give you an unpleasant, soupy mess.
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If you use 1% PE9010 + 1% Geogard Ultra + 3% Pentylene Glycol + pH =4.8, you will be in good shape
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Anca_Formulator said:@MarkBroussard Can the Euxyl 9010 Hurdle approach above be effective for a toner made with 50% organic hydrosol (from a reputable source, with a COA, but unpreserved by manufacturer) that also contains some hydrolized protein extracts? Has 5% glycols.
Sure, but you need to couple it up with Gluconolactone (and Sodium Benzoate, chelator, low pH, but it should work
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Anca_Formulator said:Thank you Mark.
@MarkBroussard What are your thoughts on Jeecide CAP 2(by Jeen): Caprylyl Glycol (and) Phenoxyethanol (and) Hexylene Glycol?
Yes, this would work in emulsified products. You would need to couple it up with Gluconolactone (and) Sodium Benzoate
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Yes, I typically used Propanediol at 3%. Caprylyl Glycol at 0.3%.
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Yes, Propanediol would function as a preservative booster. Caprylyl Glycol is a bit better as it’s mode of action is to help weaken the microbial cell wall, but it does reduce viscosity in creams.