Home Cosmetic Science Talk Formulating Molecular weight < 500 Da can be absorbed into skin

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  • Molecular weight < 500 Da can be absorbed into skin

    Posted by Dtdang on May 23, 2022 at 2:25 pm

    incredient that has less than 500 Da molecular weight can be absorbed to skin. 

    Hyaluronic acids medium, small and very small have molecular weight > 500 Da. Therefore they can not be absorbed to skin? But, it works well on the skin.
    why? I appreciate all answers 

    Thank you so much and have good weekend.

    Dtdang replied 1 year, 11 months ago 3 Members · 3 Replies
  • 3 Replies
  • OldPerry

    Member
    May 23, 2022 at 4:38 pm

    It’s a good humectant on the upper layers of the skin

  • MarkBroussard

    Member
    May 23, 2022 at 6:47 pm

    @Dtdang

    Molecular weight is only one factor that determines if a particular ingredient can penetrate the SC.  The super low molecular weight HA does indeed penetrate with the optimal being 200 kDa for HA.

  • Dtdang

    Member
    May 24, 2022 at 12:17 pm

    @Perry, @MarkBroussard
    Thank you so much 😊!

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