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Abdullah said:

localhost said:

The European Cosmetic Toiletry and Perfumery Association recommends that Tea Tree Oil should not be used in cosmetic products in a way that results in a concentration greater than 1% oil being applied to the body.

Interesting

Where can i find this data? 

I need to show it to some people

SCCP (Scientific Committee on Consumer Products), Opinion on tea tree oil, 16 December 2008

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The European Cosmetic Toiletry and Perfumery Association recommends that Tea Tree Oil should not be used in cosmetic products in a way that results in a concentration greater than 1% oil being applied to the body.

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I suppose would liken this to the difference between janitorial products marketed to institutions vs consumer cleansers marketed at grocery stores. The janitorial products are going to have reasons for their composition besides consumer appeal since the users are function oriented and the orders are on the order of pallet loads.

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Of course, but in this case they have an SDS and are being marketed for use in ESD and NSF compliant facilities I would hope that there are legit reasons behind their formulations, especially seeing as they are all incredibly similar. 

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Does it need to be in a typical deodorant container?  There is a company called pharmapump which sells airless vacuum dispensers that are pretty good.  They will send you out a sample if you ask. MOQ is 25 units at about $1 - 2 ea.

* https://www.pharmapump.com/ 

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Good to know that about the journal.  

I will take your advice.  Much appreciated.

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I’m curious how a study published in the Journal of Cosmetic Science got something like that wrong.  If it makes no sense to someone like me, how did they not realize it?

Would you mind taking a look at my formula telling me what you think?

Purified Water to 100%

Propylene Glycol 10.00%

Glycerin 2.00%

Xanthan 0.30%

Xylitol 3.00%

Petrolatum 10.00%

Mineral Oil 8.00%

Caprylic/Capric Triglycerides 3.00%

Cetearyl Alcohol (and) Polysorbate 60 3.00%

Urea 5.00%

Sodium Lactate 2.50%

Germaben II 0.50%

Buffer (50mM at pH 6.0): 

Citric Acid (anhydrous) 0.12%

Sodium Citrate 1.28%

Thanks.

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Can you explain how they get this result:

“According to the optimum result in retarding urea decomposition in aqueous solution, preparations adjusting with lactate buffer pH 6.0 were subjected to study in this experiment. Pharmaceutical preparations composed of urea at varying concentrations of 2.5%, 5%, 10%, 15%, and 20% (w/w) with pH 4.50 (no further pH adjusting) and pH 6.00 (adjusting with lactate buffer) were examined. Table V demonstrates the values of the rate constant, 4, in h” calculated from the experimental data of the residual urea concentra- tion as a function of temperature. Within the experimental range of temperature and initial urea concentration values, the lowest urea degradation was found with lactate buffer pH 6.0.“

Is it just the sodium lactate in the pH 6.0 lactate buffer giving the least degradation?

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If that link doesn’t work try this one, sorry:

* https://www.docdroid.net/i3YlHdj/urea00-pdf

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Thank you very much for your informed reply and for taking the time to address my issue.

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Pattsi said:

Couple of questions.
1. Why do you have to formulate the ointment yourself, is 12% Lactic acid cream or 20% urea cream not available in the hospital?
2. Have you consult your doctor about using this ointment, is your condition not improved with normal Vaseline, should you jump start to keratolytic dressing? Or is your doctor planning on keratolytic with topical corticosteroids? 
3. Are you confident in your formulating skill? Should you better have a pharmacist prepare the formulae?

Very appropriate questions.  Here are the answers:

1. a. Dealing with a chronic skin problem which requires multiple daily topical applications of top-tier cosmeceuticals is very very expensive — $20 for 250g of one of them, which is applied over large parts of the body.  The ingredients for these are not exotic and I see it as the equivalent of going to a nice restaurant every day for all meals instead of cooking your own.

1. b. The formulation would require a compounding pharmacy.  This would require a doctor to prescribe it — even though the ingredients themselves are available individually to consumers and are not restricted.  This is equivalent to getting prescribed an 800mg Ibuprofen pill when you could buy a bottle of 200mg pills and take four of them. 

2. a. I have not.  This condition is very rare and there is barely any evidence based research on treatments — without this doctors are (understandably) hesitant to proceed down unfamiliar treatment paths. 

2. b. In the USA, even with good insurance, it is a bureaucratic nightmare to have non-standard treatments approved.  To get them to approve a compounding pharmacy to regularly provide a mixture of over-the-counter ingredients for a dermatological condition will be — I am quite sure — a lesson in frustration and possibly futility.  And if it does get approved I still have to pay an unknown out-of-pocket cost for it.

2. c. Vaseline is indeed a great occlusive and emollient.  However it is not effective alone at mitigating my symptoms, which involve large patches of very itchy inflamed skin over 80% of my lower body, certain parts of my face and scalp, and a good portion of my chest and back.  I don’t know if you have covered your body in petrolatum before, but it destroys your clothes and furniture and generally makes life unpleasant and requires application over wet skin to be effective.  It also makes the bathroom floor a fall hazard and will clog your drains without mercy.

3. a. I am confident that I can follow instruction and data and that those are available to me — provided that I am responsible and diligent. 

3. b. If it appears that using a pharmacy is the best course of action, I will pursue that.  At this time, however, I can find no positive benefit to having a pharmacist compound ingredients if I can do it in a safe, consistent, effective, and economically advantageous manner.
  
Thanks

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jemolian said:

Just wondering, must it be 5% Salicylic acid? Because it’s can be very difficult to solubilize. 

It is probably pretty flexible.  I imagine that, as many doctor’s tend to do, he looked up the max safe dosage and is using that as long as it doesn’t cause adverse effects for the patient.