em88
Forum Replies Created
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All the final results (like stability test) should be made for the normal industrial batch you are going to put on the market.
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Have you resolved the issue? 🙂
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@mikethair, that is interesting regarding Malaysia reglementations about cosmetic manufacturing.
I work in a pharmaceutical industry and we manufacture solid and semisolid products so we have many powder ingredients and most of them require normal RH storage. Storage conditions are based in the ingredient properties and package material used to package that ingredient.
Here is an example: https://www.chemicalbook.com/ProductMSDSDetailCB3463970_EN.htm@Belassi, What does it mean correctly stored?
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Why do you need GMP if you are not making anything special?
Calibration is mandatory for any equipment you declare.
You have to have normal conditions (temperature and RH if it not required otherwise) in the prodduction site.
It is strange that you don’t have any ingredient that does not specify the storage condition including RH. -
Solubility is the only thing different. The sodium salt paraben is soluble in water at RT while propyl paraben should be dissolved in water at 70-80 C.
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Should we call in ambulance, just in case?
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Do these people eat or inhale talc?
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From the picture, your cream has air trapped in it.
Congratulations on solving the problem! -
pH 1.5 is very low already.
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Thank you for the reply. That is a PVP unspecified type (based on ulprospector). I can get some PVP for high viscosity solutions, but the problem with this is its property of being sticky.
I have observed that, first I have to make the gel in water and than add in the gel the SA solution in small proportion so it gets incorporated. Will try the same thing with HEC again and see if it will work.
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I’m in. I hope this time I will get the reminder.
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I like the idea of using premixes, they make your life easy, but they are too expensive. For example the above example is like $90 per kg
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3 yr old thread spotted.
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Calendula officinalis has antiinflamatory effects and it should be very cheap. Add some vitamin A as well and you got a great product that even I would use
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Parabens and to make your life easier go for the sodium salts of parabens, this will make them easily soluble in water.
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@amitvedakar here is a nice paper regarding the stability of ketoconazole https://pdfs.semanticscholar.org/7afb/7edf582cb706c85382a1c28fdbeec646ec48.pdf
The main problem with ketoconazole shampoos is dissolving it, but after dissolving it the next problem is stability. Ketoconazole is not stable in water solution. Within some time the impurities will increase very quickly.
I was wondering how did you manage to keep ketoconazole stable. Maybe we can talk in private and share some info together so we can optimize our formulations.Regarding the SA shampoo, the first problem I faced was the possibility to dissolve SA before adding it in the shampoo base and in the same time avoiding foam. I did this, now the process is smooth. No foam is created which means the bottle filling procedure comes immediately after the preparation.
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Is your formulation stable within the shelf life you wanted? Do you notice any degradation in those extract? If everything is ok, than pH should not be a problem if it is in the range of 5-7.
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What about adding gelling agent? Xanthan gum should do the trick. probably 0.3-0.5%.
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In india everything is possible.
There is still a problem with that formulation. In order to keep ketoconazole stable you will have to have pH around 7, this means SA has to be neutralized totally. -
Myristyl Lactate? NaCl would be the cheapest solution.
Isn’t the shampoo irritant? ALS seems to be in a high concentration.
Not sure about the huge list of oils, most likely will not do much thing. -
That is creepy
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I’m sure there are many companies that can do stability tests for you. You will need microbiology tests as well. I don’t think viscosity is requested. You should consider scale up procedures too.
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That would not lead to any reliable conclusion at all. Also stability tests are made in the original packaging and take time, not 2-3 days….
You can do the freeze and thaw cycle test at home I guess.
Regarding viscosity, you will not find the viscosity value, but you can do it by comparison and see how it changes over the time.
I’m not so sure what do you mean by “cosmetics manufacturing”, but considering what you are posting it seems kind of dangerous things what you are going to get yourself into…. -
If you notice a cloud effect after adding the oils than you should use polysorbate 20 as a solubilizer (as Perry said). From what I have red in the past, it is recommended to use the solubilizer at the same percentage as your oils.
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There are so many ways to dissolve SA and keep it dissolved in the solution, especially when the concentration is up to 3%. I don’t find it so difficult.
Looking again at the LOI of that product in 2013 you can see too many extract indicating the % for each of them is very low (most likely below 0.5%). An other thing is the combination of Salix Alba (Willow) Bark Extract and Salicylic Acid which indicates SA is less than 0.5% as well. So dissolving that little SA is very easy.
If you search in the forum @Zink have posted a good list of solubilizers for SA which you may use.