DRBOB@VERDIENT.BIZ
Forum Replies Created
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You can use Methocel E4 premium at 1-2% (HPMC) Salt will not thicken your surfactant combo.
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Propanediol will work fine:add below 45C.
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@Microformulation percent solids and %active are two different things. Sulfation via SO3 (falling film) includes NaCL and Na2SO4 and/or unsulfated alcohol.
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You are welcome:hardest part is getting it set-up but accuracy on duplicate samples (same lab) is 0.5% and between outside labs is Within 1%.
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You can start here. https://www.astm.org/Standards/D1681.htm
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Can be done easily via methylene blue titration. Ask supplier for method or look it up.
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Soap is thixotropic so viscosity increases with time so formulate in anticipation of this allowing for the increase during the shelf life.Bar soap absorbs water as a result of its thixotropy in the soap dish and gels as-compared to syndet bars which form slop/slush.One approach is a small amount of polysorbate 20 which should help.
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Trial and error to start until personal instincts kick in developed thru many TandE trials:even then T and E remains within the cycle of development.
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i think we have have a miscue-define API-I am relating to testing % active sunscreen after addition to batch for which you need a validated method?
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As you likely know you do need method validation to run actives as per FDA guidelines but 10K is high (way high).I would have it done myself and provide method to be run as per your guidelines which can be merged with FDA requirements.
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You need both an emulsifier and Rheology modifier and you can do both using a carbomer such as Ultrez 10 neutralizing the latter with equal parts by weight with triethanolamine or if you choose another base to Ph 5.5-.6.0.Does not require a lot of shear to produce cream with good sensorials.
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Ultrez 30 will provide better electrolyte tolerance and deliver sensorials similar to Ultrez 10:also very easy to work with.
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You asked two questions-the first is yes creams depending upon composition can and do exhibit a Ph shift.Carbomer based creams do not usually exhibit a PH shift at 5.5 to 6.0 using TEA. Should the need arise a small amount of 0.1 M citric acid buffer should stabilize the cream. but use as little as possible due to electrolyte sensitivity.
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We use the rule of seven to include advertising combined with the three levels as outlined above including freight/shipping gives a fairly accurate picture of the markup multiples.
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lanolin is another option but never tested it versus petrolatum TEML.
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See my e mail to you regarding safety claims process controls and raw material variations which if left to chance can effect final product.
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That will work but highly effective humectant so a 5% stock solution can be diluted in final product as low as 1%( active).Also you can use a 1% solution of hyaluronic acid wihch is available commercially also highly effective at 0.05 to 0.1%.
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Ideally you need a knowledge of the supplier side of the industry.Having worked on both sides of the industry provides an advantage for the formulator.There are hidden variables on the supplier side and asking a myriad of questions will get you where you need to go,however you need to ask the right questions which comes from experience as you will not find these instincts in a textbook.
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D panthenol penetrates the cuticle/cortex and absorbs water swelling the hair shaft.You can measure this in-vitro (TRI Princeton) but best to do salon studies as volume relates to consumer perception.
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Try an aqueous solution of D Panthenol.
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My bet is it would not pass USP/OTC challenge test.
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Yes using sodium stearate is correct.Good luck as we have done some EWG projects.
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No particularly in the case of Monographed OTC antimicrobials such as triclosan.
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Blackheads are plugs which potentiate the commodone cycle.I would avoid all oils with the possible exception of carrot oil which contains beta carotene.
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@komirra Use 0.5% wt/wt and adjust Ph at the end.