[amitvedakar]

It is true as a preservative limit is 1% in pharma in india.

But as @em88 & @perry 3% can be used as solvent    

Link shows more than 3% make irritation.

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+46.

[amitvedakar]

At PH  6.5 to 7. Ketoconazole is stable. but Will SA work at this pH.

What pH should be maintained of  SA shampoo to work SA.

[amitvedakar]

actually we made selenium sulfide + Clotrimazole shampoo.
But found clotrimazole unstable. It became blackish after a year.

[amitvedakar]

Thank you sir @Gunther.
Actually our is medicated 2.5% USP topical suspension (shampoo). 
Is Bantonite useful/necessary  in this product?
is Use of HPMC, Magnesium Aluminium Silicate  useful?
Well i saw material  Di hydrogenated  Tallow Phatlic acid amide. Why this is used?
Our product is Shampoo base. so SLES, CocoBetaine and cocoamydobutone, Citric acid, Dimethicone are my main ingredients. 

[amitvedakar]

Luliconazole 1%
ceto steryl alcohol, cetomacrogol 1000, paraffins (Jelly), parabens, Propylene glycole, Benzyl alcohol.
Actually it dissolve in Benzyl alcohol. but benzyl alcohol is 1%. can we use more than 1%?
  It dissolve in Dimethyl solfoxide. can we use in formulation?

[amitvedakar]

@em88 we dissolve it in con hcl. after dissolution we dilute it.
maintain final product at pH 6 to 7.
we purchased SA & ketoconazole combination prodct from the mkt which has 6.5 pH.  

[amitvedakar]

@em88  ketoconazole shampoo is stable as per you mentioned pH 7.
we got tested after two year.
but with SA is challenging.

[amitvedakar]

Ketoconazole 2%
Salicylic acid 2%
this shampoo is running good in india for dandruff.

Any idea?

[amitvedakar]

glycolic acid formulation has 3 to 4 ph.
While arbutin work good at 6 ph.
how to formulate of this  combination? 

[amitvedakar]

Thank you all.
I am going to experiment with sodium metabisulphite & Dipalmitate.

[amitvedakar]

Try sodium  Metabisulphite It makes cream whiter.

[amitvedakar]

Thanks sirs,

cm 1000 is ceto macrogol & EGMS - Ethylene Glycol Monostearate .
I use D.M. Water.
Will use of Sodium Metabisulphite increase stability?
The cream became brown first & than Blackish from the end of tube.
I have also added Methyl Paraben & Propyl papraben.
Image of cream as shown above.

Thanks again for your Interest & Suggestion.  

[amitvedakar]

when you work with SLES try Nacl . it might work as thickener.

[amitvedakar]

If you want to make herbal oil. you should try oil soluble amla, bhrami, bhrungraj ext. you can also try little menthol, camphor.

[amitvedakar]

dilute with 50%  with water .

[amitvedakar]

Thanks

Should I test that Blackish for microbes?
will it help to select preservative.  

[amitvedakar]

It is packed in Lami. tube. & it has also a leakage problem.