• Formulating

  Luliconazole cream

  Posted by amitvedakar on April 29, 2018 at 6:54 am

  Luliconazole 1% cream
  dissolving problem.

  Does not dissolve in PG. soluble in Hot PG but when cool it re-precipitated.
  Any idea?

  amitvedakar replied 6 years ago 3 Members · 3 Replies
• 3 Replies

• 

  Doreen

  Member

  April 29, 2018 at 7:09 am

  Formula?

• 

  amitvedakar

  Member

  April 30, 2018 at 3:50 am

  Luliconazole 1%
  ceto steryl alcohol, cetomacrogol 1000, paraffins (Jelly), parabens, Propylene glycole, Benzyl alcohol.
  Actually it dissolve in Benzyl alcohol. but benzyl alcohol is 1%. can we use more than 1%?
    It dissolve in Dimethyl solfoxide. can we use in formulation?

• 

  Bill_Toge

  Member

  April 30, 2018 at 9:02 pm

  try adding it to the oil phase; I wouldn’t recommend using DMSO in anything topical

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