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Vitamin K and Retinol
When I combine Retinol 50C (which is retinol and Polysorbate 20 and some BHA and BHT) with Vitamin K, my product turns red in color. I am using high levels of each ingredient. I decided to perform a test by adding each ingredient together and sure enough it forms a red color instantly. To eliminate any issue with ethoxylates, I tested Vitamin K with Polysorbate 20 and no color problem. Can anyone tell me what is happening? When I do test the two ingredients together, the red color is formed but no precipitation forms at least not at room temperature after a week. Any insight into this reaction would be helpful.
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6 Replies
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Since vitamin A is a yellow or orange substance, and the two vitamins are both fat-soluble, my best guess is that a reduction reaction takes place and free Vitamin A is produced.
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Electron transfer to a high energy orbital
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“I am using high levels of each ingredient.” I would not recommend this concept, and most especially not without extensive safety testing, including RIPT.
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I have noticed same color change color turns dark yellow.. with Vitamin K not A. Anyone can help?
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I think Vitamin K is photosensitive because it involves directly in plant photosynthesis. If you are making the formulation sample in a glass beaker or glass jar, did you wrap the beaker / jar with foil sheet to protect the sample from light?
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The color change is instantaneous so light exposure is not a factor. Interested in knowing more about the reduction reaction. When you say ‘free’ Vitamin A is formed from the reaction with Vitamin K then what forms - the ester of Vitamin A? Also what happens to the Vitamin K - is it oxidized?
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