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Using squalene in place of squalane
Will there be stability problems if I use squalene in place of squalane in my o/w gel cream? The % of squalene used will be just 3%-5%. If I add bht to this squalene will it prevent squalene from oxidising?
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3 Replies
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Your line of thoughts is spot on, susceptibility to oxidation is the main issue. Whether or not the added amount of BHT will suffice, only trial and error will tell.From a theoretical physical point of view (emulsion stability), squalene in a o/w emulsion might be superior to squalane in some regards but may have a negative impact due to a lower melting point of the oil phase and therefore easier droplet fusion. -
Pharma said:Your line of thoughts is spot on, susceptibility to oxidation is the main issue. Whether or not the added amount of BHT will suffice, only trial and error will tell.From a theoretical physical point of view (emulsion stability), squalene in a o/w emulsion might be superior to squalane in some regards but may have a negative impact due to a lower melting point of the oil phase and therefore easier droplet fusion.Just came across a paper on the o/w squalene emulsion.. Here’s an excerpt
“an unbuffered version of the squalene o/w emulsion MF59® experienced an unexplained loss in squalene content at 25 or 37 °C over a 3-month period”MF59 - tween 20 and span 85. -
An unexplained loss… that could mean anything, from oxidation due to poor formulation over an idiot at the work bench to a greedy boss who’s not coming up for reference substances… make a pick 🙂 .
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