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Salycilic acid shampoo
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In india everything is possible.
There is still a problem with that formulation. In order to keep ketoconazole stable you will have to have pH around 7, this means SA has to be neutralized totally. -
@em88 ketoconazole shampoo is stable as per you mentioned pH 7.
we got tested after two year.
but with SA is challenging. -
@amitvedakar here is a nice paper regarding the stability of ketoconazole https://pdfs.semanticscholar.org/7afb/7edf582cb706c85382a1c28fdbeec646ec48.pdf
The main problem with ketoconazole shampoos is dissolving it, but after dissolving it the next problem is stability. Ketoconazole is not stable in water solution. Within some time the impurities will increase very quickly.
I was wondering how did you manage to keep ketoconazole stable. Maybe we can talk in private and share some info together so we can optimize our formulations.
Regarding the SA shampoo, the first problem I faced was the possibility to dissolve SA before adding it in the shampoo base and in the same time avoiding foam. I did this, now the process is smooth. No foam is created which means the bottle filling procedure comes immediately after the preparation.
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@em88 we dissolve it in con hcl. after dissolution we dilute it.
maintain final product at pH 6 to 7.
we purchased SA & ketoconazole combination prodct from the mkt which has 6.5 pH. -
@Belassi
I’d start with Sodium Salicylate, either by reacting bare salicylic acid with dilute NaOH, or by buying premade SS.SS is way more soluble than Salicylic Acid.
You’d need to lower shampoo pH to match SA pka 2.97, to get 50% SA / 50% SS
So you’d get more than 50% soluble SS at normal shampoo pH levels
Compare that to 0% SS if starting with SA from the beginning.Many commercial shampoos have SS
https://int.eucerin.com/our-research/ingredients/s/sodium%20salicylate -
At PH 6.5 to 7. Ketoconazole is stable. but Will SA work at this pH.What pH should be maintained of SA shampoo to work SA.
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