Lidocaine HCL degrading problem - Chemists Corner

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Lidocaine HCL degrading problem

Posted by lovermanco on May 19, 2021 at 9:03 am

Hello! İ would like ask a related question about LidocaineHCL?

İ made a salve serum solution that contains %5 lidocaine HCl.İt was so basic formul.
m.p.glycol,glcerine,menthol,aqua,lido,preservative.
But its effectiveness has been degrade day by day.
how i can protect its stability? Should i do its form as a gel form?
thanks a lot.

lovermanco replied 2 years, 11 months ago 3 Members · 5 Replies
- lidocaine-serum-menthol
5 Replies

Pharma

Member
May 19, 2021 at 6:29 pm

A: In many countries, lidocaine 5% is considered a prescription drug

B: It’s light sentitive

C: pH for best stability is 6-6.5

D : You may want to add BHT or similar to increase stability

E: What the heck is a salve serum solution?
lovermanco

Member
May 20, 2021 at 10:07 am

thanks for feedback Mr.Pharma.
somebody told me clove oil can support its efficiency.Could it be true?
Pharma

Member
May 20, 2021 at 6:33 pm

Clove EO contains mostly eugenol which is, like lidocaine, a local anaesthetic. Cloves were used for centuries against toothache.

Pro: Very good skin penetration

Con: Strong smell and rather short action because of fast resorption and volatility
Pattsi

Member
May 21, 2021 at 7:16 am

clove oil, Lidocaine, menthol - I can see where this is going.

Are you sure you want to use menthol and clove oil? They can sting the inside of the recipient.

Make sure you do the irritation test properly.
lovermanco

Member
May 28, 2021 at 12:54 pm

Thank you for all response.
i am gonna discard the menthol and i ‘ll make an emulsion wth lidocaine and clove oil.

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