Home Cosmetic Science Talk Formulating Face serum separation

  • Face serum separation

    Posted by mmarr on January 11, 2024 at 7:52 pm

    Hi everyone, I faced a problem where when we formulate face serum and doing small scale in lab the face serum doing good. but when we produce in production it become separate in very short time. Anyone can suggest why this happened?

    I checked ingredients, its unlikely cause separation because all water soluble. btw, can I save this product? adding some liquid emulsifier? or really cannot?

    here i attached formulation:





    glycol distearate-1.0

    aloe vera







    mikethair replied 1 month, 2 weeks ago 4 Members · 7 Replies
  • 7 Replies
  • graillotion

    January 11, 2024 at 10:37 pm

    Have you tried a knock-out….removing the Aloe?

    • mmarr

      January 11, 2024 at 11:20 pm

      no, not yet coz in the lab, there is no separation. Can it because of the processing issue?

      • mikethair

        January 12, 2024 at 1:52 am

        In my experience (20+ years manufacturing) if there is no separation in the lab, but it separates in production, I would be looking at the SoPs for this product. Perhaps the SoPs are not being followed by your production staff.

        • mmarr

          January 14, 2024 at 6:42 pm

          okay, will check on it. thanks @mikethair

          • mikethair

            January 14, 2024 at 11:37 pm

            If you would like to share with me the particular SoPs for this product, I would be willing to provide my comments. Please email me at: mikethair@gmail.com

            Kind regards,

            Dr Mike Thair

  • Bections

    January 16, 2024 at 9:04 pm

    Production environments may have different temperatures and mixing procedures than your lab. These changes can affect how basket random components interact and lead to decomposition. Do you adjust the mixing process for larger batches?

    • mikethair

      January 16, 2024 at 9:18 pm

      Excellent point, temperature can be a factor in the production of many products. And as you mention, there are other factors as well.

      We produced SoPs for the production of every product we manufactured, and since we were manufacturing in Malaysia and Viet Nam we learnt that these are VERY important.

      I’m amazed that many companies don’t bother with developing a QC system, including product SoPs.

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