EDTA and cell membrane disruption?
I have spent the past couple of weeks, trying to create a blurb for beginners wanting to use more ‘natural’ preservatives. Of course this has morphed into a monstrous beast of a blurb….as a program like this must pull in every aspect of hurdle formulation.
I thought I knew EDTA, inside and out….but came across this quote the other day, and before I used it…wanted to confirm the validity of the concept. So evaluate this comment:
Also, chelators (such as EDTA, nitrilotriacetic acid, and sodium hexametaphosphate), which disintegrate the outer membrane by removing Mg2+ and Ca2+, are effective and valuable permeabilizers.
In summary…they were saying…. EDTA would actually pull/bind/tie-up Mg2 and Ca2….right out of the pathogens cell membrane…therefore performing the partial role of a cell membrane disruptor. I had never actually looked at it in this exact light. Would those of you that specialize in this field…concur with that statement and concept? …. EDTA does function as a cell membrane disruptor, via this mode of action?
For those of us that work with the next level down with chelates like…. GLDA….would we also get the same benefit?
Aloha…and looking forward to your answers, one and all. @PhilGeis
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