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DMAE
Has anyone here designed a DMAE product? Looking for experience and opinions. Thinking of creating a 3% gel.
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15 Replies
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https://www.hindawi.com/journals/tswj/2014/507351/ is encouraging. I cannot find any data on pH.
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It appears that I am the only person here that’s investigating this. Oh well. I shall proceed on my own… step 1: Investigate pH in possible mediums.
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I have used DMAE as part of an anti-aging cream. It was easily incorporated. The only real downside is the odor.
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The powder I have doesn’t smell of anything and nor did a 2% solution, but I imagine that the fragrance of the solution, a skin cream, may have masked it.
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@Belassi that sounds very suspicious; monoethanolamine has a very strong fishy smell, so DMAE (its N,N-dimethylated derivative) is likely to have a similar smell
also, looking at online data, it appears the melting point of DMAE is −59°C, so by rights the pure substance should be a liquid at room temperature
for that reason, I strongly suspect that whatever you have is not DMAE
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http://ilextropica.com/supplements/dmae/ is where I got it from.
So it looks like I have the bitartrate salt. -
It’s in Portuguese but can easily be understood
Como fazer Como fazer Creme com DMAE, Aprenda a fazer receitas de cosméticos passo a passo e tudo gratis varias formulas de facil manipulação veja aquiComo fazer Creme com DMAEformula igual do mercado serve para muitas correções, principalmente para flacidez do rosto e maçãsLista de IngredientesDosagens para o Rosto:bitartarato de dmae ……………8g (dissolva em 10 ml de água.)vitamina E oleosa ……………..5gqsp 100g de base não iônica (Obs: A base é “não ionica” das empresas Chembase ou Croda)Como fazer: Misture bem até ficar homogeneohttp://www.soformulas.com/cosmeticos/como-fazer-creme-com-dmae.html
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So that is 8% DMAE bitartrate and 5% vitamin E in a non-ionic surfactant solution?
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That’s right, 8%In fact, 8% may not be an exaggerante amount after all (just considering technicals, not costs) as an study used 3% concentration:In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious (p < 0.05) in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but </= 0.1) were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. Application was found to be well tolerated, with no differences in the incidence of erythema, peeling, dryness, itching, burning, or stinging between the DMAE and placebo groups. An open-label extension of the trial showed that the long-term application of DMAE gel for up to 1 year was associated with a good safety profile.I really want to find out what study they’re talking about as the one cited is just a review article.
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I’m not sure if they’re discussing this study:Full-text available hereBut they don’t describe the gel composition.
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My initial tests are enough to convince me that I want to continue. There seems to be no pH issue; the last test was in a cream containing pycnogenol, which is an indicator. The light pink colour of the cream stayed the same.
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It is interesting that DMAE bitartrate comprises only 37% active DMAE
Pure DMAE mol wt 89.14
https://www.sigmaaldrich.com/catalog/substance/2dimethylaminoethanol891410801011?lang=en®ion=US
DMAE bitartrate salt mol wt 239.22
Thus 8% DMAE bitartrate
is 2.98% active DMAE. -
Ah that is interesting. However, we have no idea as to the relative activity level of either substance…
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Were you able to figure out what they meant by
DMAE + Amino acid compound?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123624/ -
No, Gunther. No idea.
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