-
DMAE and Apprecier
After trialling a 3% DMAE skin cream (a basic cream without any other actives) I am minded to add DMAE to our Vitamin C formulation.
It’s 2% L-Ascorbyl 2-Phosphate 6-Palmitate Sodium (Apprecier) and I am concerned as to possible reactions between them - I’d like to use 2% DMAE.
The formula is stabilised with 2% pycnogenol and pH is around 5. The preservative is KEM NAT I don’t expect any issues from that. It seems to me that the C is in the form of a complicated salt, and the DMAE is a salt; my tests have shown so far no appreciable change in pH from adding DMAE. -
2 Replies
-
DMAE, Diaminoethanol
as the name says has 2 functional groups:
Amino ( N-CH3 ) and alcohol ( -OH )
the amino one can react with acids, so it’s better to have it in salt form to avoid cross-reactions.
https://www.sigmaaldrich.com/catalog/product/sial/38990?lang=en®ion=USThe alcohol group ( -OH ) in DMAE ain’t that reactive. Fatty alcohols and glycerin have one.
L-Ascorbyl 2-Phosphate 6-Palmitate Sodium has a lactone group (the ring with the
-O- )
http://www.sdk.co.jp/english/products/110/114/12696.htmlLactones may react with ethanolic ammonia
https://en.wikipedia.org/wiki/Lactone#Reactions
I don’t know whether the amino group from DMAE will react too, but to be safe, that’s another reason to have DMAE in salt form.You can try keeping some concentrated DMAE + Apprecier solution warm for several days to see if a precipitate, or any other visible change forms.
Beyond that you’ll need 6-figure lab equipment to check for cross-reactions.
HPLC to look for diminished DMAE/Apprecier concentrations, and GC-MS, NMR to look for new chemical bonds from cross reactions. -
Thanks. I will be using DMAE tartrate.
Log in to reply.
