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Cream Formulation Help
What would be the purpose of aluminum sulfate, calcium acetate, dextrin, and maltodextrin in a cream formulation? What are the typical use levels for each ingredient?
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4 Replies
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What do you want the cream to do?
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@Perry it is an anti-itch cream, similiar to cortizone
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Aluminium sulfate is an adstringent, mild disinfectant, and somewhat deodorising agent. It’s less aggressive than aluminium chloride and used at lower %. Adstringents (synthetic, natural, or mineral) help against itching due to inflamed skin conditions (e.g. stings, rashes) which tend to produce exudate or feel wet due to increased skin porosity. Calcium salts (acetate is one of the few highly water soluble ones) serves as a traditional anti-itching and vasoprotective agent (for example as calcium dobesilate wherein dobesilic acid greatly contributes to the effect); they also help to speed up blood clotting. Dextrin and maltodextrin may be fillers, honey replacements, humectants, structural agents… nothing special.PS If it’s “similar to cortisone” than it does contain a drug such as a cortisone derivative, an mTOR inhibitor, or the like. Though usually, such creams are not “similar to cortisone” but “like a cortisone cream without cortisone” = just a cream. -
@Pharma thank you for the explanation! and yes it contains hydrocortisone, I need to achieve a consistency similar to that of the cortisone creams so I wasn’t sure if those ingredients above were more so for texture or if they had a different purpose.
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