Home Cosmetic Science Talk Formulating Skin Climbazole leave on lotion (moisturiser)

  • Donmattus

    January 11, 2017 at 12:15 pm

    Thank you for all your help with this. 

    The end result seems to be good for most of my face but it is not good for my eyebrow areas (which are the sensitive bits - I don’t think it is an allergy to the silicone, just it doesn’t soothe the irritated skin enough so it is too uncomfortable to leave on for any length of time). I see the benzyl alcohol is soluble in water 1g to 25ml water https://pubchem.ncbi.nlm.nih.gov/compound/benzyl_alcohol#section=Solubility so I wondered if it could be added to aloe vera? 

  • johnb

    January 23, 2017 at 10:14 am

    According to the data sheet for Crinipan AD (climbazole), it is soluble in alcohol and glycols.

    Try dissolving your climbazole in a glycol (propylene glycol, propane 1,3 diol, butylene glycol, isopentyl diol etc.) and slowly diluting with water until precipitition occurs. This will give you an idea of the concentration of glycol necessary.

    You don’t need anything more that this - a simple solution of climbazole in glycol/water. Provided there is sufficient glycol present (20% or so) you don’t need a preservative or stabilizer.

    Climbazole is now available in the UK from http://www.naturallythinking.com/ priced at 10g for £5. Larger pack sizes are available.

    The product is of European origin and is a repack of Crinipan AD (Symrise).

  • Donmattus

    January 23, 2017 at 1:47 pm

    Hi Jon, I know I have replied on the other forum but thanks for the link - that is very helpful indeed. 

  • belassi

    January 23, 2017 at 3:09 pm

    Price rules that out for a commercial shampoo. Think I will talk to Symrise directly. They have a branch in Mexico.

  • johnb

    January 23, 2017 at 3:20 pm
    Price rules that out for a commercial
    shampoo. Think I will talk to Symrise directly. They have a branch in

    That is a small user price. I’m sure the commercial rate is much lower than that.

  • Pete

    January 25, 2017 at 6:04 pm

    Hi Donmattus, I haven’t been following this discussion until
    just now, but a quick look on the internet mentioned a relatively recent and successful clinical
    trial using oral itraconazole (DOI: 10.1007/s40257-015-0133-9) which is used where patients show extensive SD
    resistance to topical therapies. Maybe it is mentioned somewhere in your above discussion and I have missed it, but thought it worth adding in case it helps.

Page 2 of 2

Log in to reply.