Climbazole leave on lotion (moisturiser)
I am trying to make a climbazole leave on lotion. I need to make my own because the ones on the market are no good - they either have food grade oils for malassezia (the thing I am trying to target as it is the cause of seborrehic dematitis) or chemicals that give me a bad skin reaction. I am first dissolving climbazole in MCT oil (MCT oil can’t be metabolised by malassezia). Climbazole dissolves in MCT oil at 96.8C but it reduces its half life to 90 days so I am making 3 months supply at a time max. I then need to incorporate the climbazole/mct oil into a leave on lotion. I have adapted 2 recipes trying to eliminate any chemicals my skin has reactions to
Heat 10ml MCT oil to 96.8C
Add 0.3g climbazole
Cool to 75C
Add 2.5g BioGreen Emulsifier
Heat 80.95ml distilled water to 70C
Add 2ml vegetable glycerin
Add 0.25g citric acid
Cool to 40C
Dump oil phase into water phase
Cool to 40C
- Add 4ml Leucidal Liquid SF
My question with this recipe is 1) whether a self emulsifier, such as BioGreen, will enable the climbazole to target the malassezia or will the lamellar layers prevent this? and 2) whether there will be an interaction effect between the lactobacillus ferment (Leucidal Liquid SF) and the climbazole?
Or whether I need to use a different emulsifier recipe such as:
MCT Oil – heat phase 1 to 70C
Climbazole dissolved in MCT oil
Ceteareth 20 (emulsifier) (HLB = 15.2 = 4.3% of 2.5% total)
Cetyl Alcohol (thickener)
Glyceryl Stearate SE (emulsifier) (HLB = 5.8 = 95.7% of 2.5% total)
Distilled Water – heat phase 2 to 70C
Vegetable Glycerin (VG, surfactant)
Citric Acid (reduce pH to 3.5)
Leucidal Liquid SF (preservative) add below 40C
I’ve added the DL Panthenol and Allantoin in here as anti irritants and I will also add in calendula extract in glycerine when it arrives! With this recipe do you think there is sufficient emulsifier (2.5%) or should I be using more (4%)?
Any advice or thoughts on these would be really helpful.
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