Members Directory - Chemists Corner

Zink

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July 9, 2015 at 11:37 pm in reply to: How would you formulate a salicylic acid moisturizer for acne prone skin? Proposal within

I intended this as a kind of open ended discussion about what type of formulation would be the most effective as a base for salicylic acid - e.g. an emulsion like I proposed, or perhaps a water or silicone based formula.

Ideally there’d be studies comparing its efficacy vs acne in different types of vehicles, but I’m not aware of any looking at that.

Zink

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July 5, 2015 at 12:46 am in reply to: Your favorite water based moisturizing ingredients (humectants/skin protectants) compatible w pH 2.

Yup I know this, so as for moisturizing ingredients?

Zink

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June 25, 2015 at 5:16 pm in reply to: Azone/Laurocapram 1-Dodecylazacycloheptan-2-one - experience with it used as a penetration enhancer?

Let’s see if there are any good reasons not to use it first, one paper anecdotally mentioned risk of accumulation in the skin.

Zink

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June 25, 2015 at 5:15 pm in reply to: Dimethyl Isosorbide - Better than Propylene Glycol as a Benzoyl Peroxide solvent & penetration aid?

Or why not Butylene Glycol

Zink

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June 25, 2015 at 5:15 pm in reply to: How would you formulate a salicylic acid moisturizer for acne prone skin? Proposal within

Formula works just fine, rock stable over 6 months at 45C. In fact It’ll work with twice the amount of oil.

I was more so wondering what changes would make it more effective as an acne treatment.

Zink

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June 15, 2015 at 6:47 am in reply to: Lauric Acid: Why does it taste like soap alone, but not in Coconut Oil?

Thanks Ruben, that sounds very plausible and takes me back to the value of even tasting (a totally safe ingredient already in food) - some people see good effect using coconut oil for e.g. eczema, then if purified lauric acid is a fundamentally different chemical, it’s also plausible it won’t work the same as the lauric acid found in coconut oil.

Zink

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June 13, 2015 at 8:39 pm in reply to: Lauric Acid: Why does it taste like soap alone, but not in Coconut Oil?

Lauric acid is not toxic, hence fine to taste. The reason to taste em is the same as to smell them, you can for instance taste differences in different coconut oil suppliers, but it’s frankly besides the point and sidetracking the conversation.

Could it be that lauric acid in purified form is somehow different from the one in coconut oil, and it makes me wary to use it on the skin in a moisturizer as it tastes like soap.

Zink

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June 12, 2015 at 9:41 pm in reply to: Lauric Acid: Why does it taste like soap alone, but not in Coconut Oil?

Why do you smell your raw materials?

Zink

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June 5, 2015 at 7:18 pm in reply to: Mixing, adding, combining, joining - what’s standard nomenclature for describing formulation methods

@DavidW not really worried, just wondering if there’s a generally normal/accepted nomenclature

@chemicalmatt that makes sense, also in cases where the order makes a difference, but you don’t know it yourself (you just know that the order you add the raw materials in works).

Zink

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May 25, 2015 at 3:56 am in reply to: Most effective anti itch ingredients? OTC/Non OTC

So using pramoxine hydrochloride I’d have to get a contract manufacturer to make it and do a FDA new drug registration I believe, but where do people source this? China?

Zink

Member

May 22, 2015 at 5:59 pm in reply to: Concealer: How to give a liquid concealer more staying power?

Thanks @Bobzchemist

Hopefully my current tweaked formula will suffice, but could look into the above if not

Zink

Member

May 22, 2015 at 1:57 am in reply to: Most effective anti itch ingredients? OTC/Non OTC

Don’t think that helps much, still looking for advice, I guess it’s time to ask eczema prosumers?

Zink

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May 22, 2015 at 1:56 am in reply to: Concealer: How to give a liquid concealer more staying power?

Tried a >10% isododecane version and also replaced propylene glycol with alcohol as a salicylic acid solubilizer. This lead to the formula being a lot drier on the skin, and it seems like staying power has improved - awaiting further testing of that.

Since this is a mostly “natural” product, not using a silicone or propylene glycol can pay for itself marketing wise.

Overall happy with the result, thanks!

Zink

Member

May 22, 2015 at 1:54 am in reply to: Alternatives to propylene glycol as a salicylic acid solubilizer?

What I’m not as sure of is how effective SA is in a mostly oil based formula.

Zink

Member

May 21, 2015 at 11:06 pm in reply to: Alternatives to propylene glycol as a salicylic acid solubilizer?

Ah yes forgot to mention, It’s oil based, I used castor seed oil and alcohol and that worked well (both are on the charts).

Cheers,

Johan

Zink

Member

May 21, 2015 at 5:45 pm in reply to: Alternatives to propylene glycol as a salicylic acid solubilizer?

To revisit this issue for a specific formula!

I’m making a water free thick “anti acne” concealer paste, and wondering if I could perhaps use castor seed oil in conjunction with alcohol to solubilize the SA, instead of say proyplene glycol?

Zink

Member

May 18, 2015 at 5:30 pm in reply to: Best preservative for pH > 7 liquid mud / clay face masks?

Thanks @MarkBroussard

Do you know anything about how Ethylhexylglycerin compares to Diazolidinyl Urea (and) Iodopropynyl Butylcarbamate or were you thinking of using the together?

Any obvious disadvantages of reducing pH to 6? I’m using 5-10% calcium carbonate so It might not be practically viable to do so.

@EliseCortes

Not really looking to replace it, rather add another preservative.

Zink

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May 14, 2015 at 6:07 pm in reply to: Most effective anti itch ingredients? OTC/Non OTC

It’s not an exhaustive list

Zink

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May 14, 2015 at 6:10 am in reply to: Professional Appearance and Tattoos

I think it might depend on the content of the tattoos lol

Zink

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May 13, 2015 at 2:09 am in reply to: Retinol sourcing: Buy < 1kg quantities?

FormulatorSampleShop said it’s 1% retinol, making it cost prohibitive.

Zink

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May 12, 2015 at 8:37 pm in reply to: Concealer: How to give a liquid concealer more staying power?

Going to try to replace 10% of the oils with isododecane and see if that helps with staying power, the Ganex sample will arrive later (min order 40lb @ $25 - 37/lb).

Zink

Member

May 12, 2015 at 5:38 pm in reply to: Concealer: How to give a liquid concealer more staying power?

Ganex V220, only one I could find on ulprospector

Zink

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May 12, 2015 at 1:01 am in reply to: Retinol sourcing: Buy < 1kg quantities?

Thanks @MarkBroussard

I’l ask FormulatorSampleShop about the retinol concentration of their liposome product, a little disconcerting that they don’t state it and there’s no data sheet to be found.

Right now trying to find something bridging the sample to 1 kg stage, seems there aren’t any great options.

Zink

Member

May 11, 2015 at 9:43 pm in reply to: Concealer: How to give a liquid concealer more staying power?

Maybe misinformation from makingcosmetics then, I’ve ordered a sample of Ganex and Isododecane to see where those will get me. How about a larger % wax?

Zink

Member

May 10, 2015 at 5:59 pm in reply to: Concealer: How to give a liquid concealer more staying power?

Thanks, I also asked makingcosmetics.com for tips, and they said:

“40% vegetable oils is a very large percentage for a concealer (also in terms of greasiness). I’d recommend to lower the amount and replace a large part of the vegetable oils with hydrocarbons such as isododecane, isoeicosane or, a natural variation, squalane or squlane light.

At the same time I would try to increase the percentage of waxes a bit as these help to increase coverage duration.”

Thoughts on combining squalane and isodedecane?

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