Thanks @Perry for you reply. The reason I mention the buffer is only because Lonza recommends it. I got their PDF about the preservative and that is what is recommended.
I did test both of them and the final pH of the cream changed significantly, so thanks on the info about the acid groups!
I am just back to formulating, and I still have tons to learn, so I’m very grateful to be accepted here! Thanks for sharing all your knolodge Perry!