PhilGeis
Forum Replies Created
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Suggest starting point for all cosmetic claim veracity is it’s hype until relevant data demonstrate otherwise. Ask for the relevant data.
For the above, found the following- “Sodium dehydroacetate-containing moisturizers have also been reported to reduce surface sebum and pore size, especially in a combination preparation with niacinamide (https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.2012.10859.x).
Also saw something on in vitro testing. -
There’s a Eurofins lab in Bucharest that offers cosmetic testing.
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Appreciate your concern for effective preservation but you can NOT do this yourself. Not sure how you would even attempt this as you will need to add microbes.
You must submit your product to a qualified lab.
The system addresses bacteria, esp. Gram negative bacteria, and needs something that will address fungal contamination - do you know pH of your product? -
Thanks for the info Perry - this is shameful. I know they’ve gone woke but sad to see P&G giving into extortion
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pH not withstanding, that is very poor preservation.
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EWG formerly hot a piece of the action (sales0 for their “certifications.” That still their practice?
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This may violate the Geneva Convention https://www.icrc.org/en/doc/war-and-law/treaties-customary-law/geneva-conventions/overview-geneva-conventions.htm
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DaveStone said:What are the scientifically supported anti-aging ingredients (if there are any)?
closing time
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30 minutes - this allows enough time thag heat penetrates
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I dont have that information
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Just benzoic - I understand sorbic is not so enhanced.
https://www.sofw.com/en/sofw-journal/articles-en/47-home-care/1703-enhancing-antimicrobial-efficacy-of-sodium-benzoateI’ve no access to the article but I recall SLS and an isethionate
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Use hot water - 80C
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Tyically sprayed.
Tanks are a problem - you’ll approach a flammability/exp[osion hazard in a closed vessel. Can you use hot water?
You should sanitize all product contact surfaces, -
tens of seconds to 1 minute on a clean surface
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ketchito is correct, and P&G has relied on that phenomenon as a an element of preservation for most of its shampoos - but typically with EDTA and an isothiazolinone or benzyl alcohol. Not aware salicylate at its pKa would help or shares the surfactant interaction phenomonon.
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All those. - everything that touches product.
Alcohol is best for surfaces and small objects - that should be cleaned before santizatiion and covered until used. Tanks, lines, flow paths best with heat (hot water or steam ) and in an assembled florm through proess.. Chemical sanitization (hypochlorite) requires rinsing and that demands high standrd foir rinse water. -
Piroctone is a chelating agent. As a hydroxamic acid like Pyrithione Zinc, it has antifungal function.
This explains https://findanyanswer.com/what-is-the-pka-of-a-drug
The protonated acid is the active antimicrobial. DHA pKa~ 5 - so 50% dissociated at pH a little over 5 (haf proitinated, half ionized - salt). Higher pH shifts to dissocated/ionic salt that is not active. In product, other ingredients may effectively change pKa - e.g. benzoic acid and surfactants. -
Sanitization to kill microorganisms, esp. those that can contaminate product. Many use alcohol - esp. 70% ethanol.
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Acetic acid is not a preservative - except as an acidulant.
Abdullah. It’s has chelator function like ZPT, not so cost effective as a preservative and has found little use in that context. Don’t think it’s on the positive lists. -
Do you guys get much analytical composition data with your essential oils?
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Consider Phenoxyethanol - for that there is a lot of data for EHG boost. I’d be cautious re a sales rep’s suggestions for their own products. Think you may have a fungal gap. Perhaps add an organic acid.
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How do you sanitize?
How would your op’s commpare to these guidelines? https://www.fda.gov/cosmetics/cosmetics-guidance-documents/good-manufacturing-practice-gmp-guidelinesinspection-checklist-cosmetics -
Why do you need Hexamidine? You’ve got two others
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What is the microbiological quality of your manufacture?
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Neither is esp good. Suppose your policy prevents isothiazolinone. I’d prob use #2 and add EDTA and NaBenzoate. Better check stability in PET. Suggest ISO AET with added cepacia.
What is your making risk?