Which of these two preservatives is stronger?Posted by abdullah on August 9, 2021 at 2:48 am
Which preservative is stronger?
1. 90% phenoxyethanol+ 10% caprylyl Glycol
2. 90% phenoxyethanol+10% Ethylhexylglycerin
MemberAugust 9, 2021 at 9:56 am
As usual, the correct answer is ‘It depends’ .
MemberAugust 9, 2021 at 10:05 am
As Pharma said - and neither is esp good vs fungi. nor shlould be considered a complete preservative system.
MemberAugust 9, 2021 at 4:31 pm
What is your metric for “stronger?” Perhaps you could better say “more effective.” In that case, like in every preservation system, this could be objectively graded solely by PET/Challenge Testing.
MemberAugust 9, 2021 at 6:56 pm
But if you would ask which one I like more, No. 2 is the answer
1. usage between 0.75 - 1.5%, pH range 4-8. heat stable “only” to 80°C
2. usage between 0.5 - 1%, pH range <12, heat stable.
MemberAugust 10, 2021 at 12:59 pm
Answer to specific question is neither - they’re both just phenoxy with a little extra boost and each could be argued a little better than the other. To get a functional answer re. a complete system, you’d need to include product formula, package and making quality dynamics.
As Microformulation said, challenge test is metric. That’s all you have, but it’s not validated to making or consumer use. FDA enforcement reports - no doubt every cosmetic recalled passed a (at least USP) challenge test. It’s a price of entry but good and poor systems pass - and the very great number of recalls in recent years is primarily associated with this prob pass and certain primary reliance on politically-correct, marginal preservatives. I’d classify as such cap glycol, glyc caprylate and other esters, PEA, EHG, cap hydroxamate, gluconolac tone, etc. Maybe not only due to the preservative systems - alone they’re poor but the typically small to moderate sized companies recalling products likely have a poor understanding of micro risk control in formula, package and making context.
MemberAugust 11, 2021 at 4:45 am
@PhilGeis it is
SLS/SLES/CAPB/APG @3/7/2/2 active surfactants.
Cationic guar 0.2%
Amodimethicone emulsion 2.5%(0.75% silicone)
Guar gum 0.1%
The bottle is HDPE but i want to change to PET to reduce the cost.
with flip top cap.
Sizes 200ml and 500ml.
MemberAugust 11, 2021 at 1:07 pm
Neither is esp good. Suppose your policy prevents isothiazolinone. I’d prob use #2 and add EDTA and NaBenzoate. Better check stability in PET. Suggest ISO AET with added cepacia.
What is your making risk?
MemberAugust 12, 2021 at 10:28 am
What is the microbiological quality of your manufacture?
MemberAugust 13, 2021 at 6:56 am
@PhilGeis i think it is good.
I make shampoo in 200kg tank each time.
I wash the tank properly after emptying the tank and before using it again.
When not in use, the tank is in the same room with raw materials, completely dry. During use we shift it to another room.
All other equipments are cleaned, used and stored like this.
I haven’t used alcohol to clean the tank or other equipments yet.
MemberAugust 13, 2021 at 10:37 am
How do you sanitize?
How would your op’s commpare to these guidelines? https://www.fda.gov/cosmetics/cosmetics-guidance-documents/good-manufacturing-practice-gmp-guidelinesinspection-checklist-cosmetics
MemberAugust 16, 2021 at 10:32 am
Sanitization to kill microorganisms, esp. those that can contaminate product. Many use alcohol - esp. 70% ethanol.
MemberAugust 16, 2021 at 4:49 pm
All those. - everything that touches product.
Alcohol is best for surfaces and small objects - that should be cleaned before santizatiion and covered until used. Tanks, lines, flow paths best with heat (hot water or steam ) and in an assembled florm through proess.. Chemical sanitization (hypochlorite) requires rinsing and that demands high standrd foir rinse water.
MemberAugust 17, 2021 at 2:36 pm
tens of seconds to 1 minute on a clean surface
MemberAugust 17, 2021 at 4:45 pm
Tanks are a problem - you’ll approach a flammability/exp[osion hazard in a closed vessel. Can you use hot water?
You should sanitize all product contact surfaces,
MemberAugust 17, 2021 at 6:08 pm
Use hot water - 80C
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