PhilGeis
Forum Replies Created
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It is a scam - do not use this junk in any application..
https://www.ingentaconnect.com/content/govi/pharmaz/2007/00000062/00000008/art00007
https://pubs.acs.org/doi/abs/10.1021/jf0514064 -
Me too Perry. Here’s what they say about % -
The agency has reviewed the
recommended concentrations of
colloidal oatmeal reported in the
literature and reference texts (Refs. 4, 29
through 32, 34 through 45, 47, 48, and
49) and has considered the range ofoncentrations for colloidal oatmeal
used in bath additive products and in
other dosage forms. Products containing
colloidal oatmeal have been formulated
in the following dosage forms: Lotion (1
and 10 percent colloidal oatmeal),
cleansing cream (8 percent colloidal
oatmeal), shampoo (5 percent colloidal
oatmeal), and cleansing bars (30, 50, and
51 percent colloidal oatmeal) (Refs. 4,
46, and 47). The agency has calculated
the approximate minimum and
maximum concentrations of colloidal
oatmeal that have been used as follows:
For regular colloidal oatmeal, a range of
0.023 to 0.625 percent when used as a
tub bath soak (Refs. 29, 34 through 38,
and 44), a range of 0.24 to 1.2 percent
when used as a foot bath soak (Refs. 30,
31, and 34), a range of 0.24 to 15 percent
in aqueous solution when used in a wet
pack (Refs. 30, 31, 32, 34, and 45), and
a range of 3.75 to 15 percent in aqueous
solution when used as a topical lotion
(Refs. 30, 32, and 34); for oilated
colloidal oatmeal, a range of 0.003 to
0.03 percent when used as a tub bath
soak (Refs. 35 and 39 through 43). -
From OTC Skin Protectant Monograph (https://www.govinfo.gov/content/pkg/FR-2003-06-04/pdf/03-13751.pdf)
(f) Colloidal oatmeal, 0.007 percent
minimum; 0.003 percent minimum in
combination with mineral oil in
accordance with § 347.20(a)(4).(g) Dimethicone, 1 to 30 percent
(l) Mineral oil, 50 to 100 percent; 30
to 35 percent in combination with
colloidal oatmeal in accordance with
§ 347.20(a)(4). -
emma - have you challenged phases separately and through cycles of shaking?
Think you’re approach preserves the oil/water interface more so than the preserving the oil phase per se.
Don’t presume the product is biphasic by intent. They may not have been able to establish stable emlusion. -
Marina - did the original prroduct have a PAO?
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Glyceryl’s undecylenate and caprylate with or without gluconate is a lousy system. any idea pH?
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Evolution is not rationale. Sebum secretion, oily hair et al. are not the results of reasoning or purpose satisfaction. They are the result of evolution, and their maintenance in current humans may or may not be based on some function we can observe. Might be remanant or result of some obsolete function.
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Re. 3. Real weak system - you need more than that.
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Abdullah said:The question i think about several times a day is what does the companies that sell the largest amount of beauty products for example Shampoo do that people are buying there Products instead of there competitors?
The simple answers that every one would give is good marketing or good quality or affordable price. But this is not the right answer. If you do good job at these parts your sells will not increase or increase for a short time and then decrease again to the level before.
So what are they doing or have done that they have succeeded this much?
You +/- describe P&G’s basic practice that has been successful globally with Pantene and Head&Shoulders - quality with effective product and advertising/ marketing. Tho’ can add continued product improvements/”news’ - real or contrived.
What may not be evident is the “effective” element both for product development and advertising/marketing. Knowing consumers - what they want and what appeals to them - as well a investing in the technology so products are (and perceived as) more effective. There are peripheral elements shelf placement , response to consumer complaints, active patent defense, etc. -
Be consistent in your practice but be aware 1:10 dilution of your product is not your product.
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Yup - bunch of jerks.
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45 kg. Dang. Supplier contract with the jerks didn’t offer any help?
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Don’t understand why they make such a big deal of CoA. Did they offere that one for cosmetics?
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Abdullah said:
It is unstable emulsion and creaming is happening.leaf water as first ingredient and not stable emulsion. preservatives don’t work correctly in my experience in unstable emulsions. How much is the shelf life of this product?
Good point! They should consider micro stability in context of each distinct phase and consumer use through frequent shaken suspensions and separations.
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Abdullah said:@Pharma @PhilGeis this product doesn’t have anything other than water and chelating agent. Why would microbes grow there?
How much phytic acid and hexametaphosphate makes 1L hard water soft?
Bacteria can grow in distilled water - there is no need for what folks think of as “bug food”.
How much theoretically depends on how hard you anticipate water to be.
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As Pharma said, you’ll need a preservative and prob a sodium salt of EDTA..
Eco-friendly - gack - meaningless advertising for the rubes. Your proposed use is irrelevant to the environment. -
EDTA does disrupt microbial biofilm.
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Great comments from pharma.
chickenskin said:
@PharmaThank you for the thoughts on this. For interactions you answered what I was looking for. My plan is to make a cream with about 10%-15% Progesterone. This will not be labeled with any claims or intended use/dosage. Can’t find much on the web beyond basic compounding formulas using stock base from PCCA.
No claims? Why are you using the stuff?
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Ask for the lab so you can directly inquire. I’d not work through a broker. I think ISO 17025 does not address technical elements of tests per se but more the management, flow and supporting elements like calibration.
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Chemicals can have effects - in “essential oil” or otherwise.
e.g. vicks VapoRub https://www.scirp.org/journal/PaperInformation.aspx?PaperID=53518
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QC micro should be on your ZPT spec.
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Think you’d find it - at some level.
In addition to reproducibility, wonder at the risk assessment re. levels found. Press release refers to 2 ppm benzene in sanitizer. There, focus was on technical/industrial grade ethanol and FDA saw 2 ppm as acceptable for limited exposure in context of need for santiizers. https://www.fda.gov/media/136289/downloadThere is the soft drink - benzoic acid/vitamin c /benzene issue.. Here they were talking about ppb levels. https://www.fda.gov/food/chemicals/benzene
Valisure is a new bunch - founded in 2015 - wonder how much of this is publicity., even if accurate as reported.
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I’d 1st decide what is “natural.” Obtained unchanged from nature of the head fake of naturally derived, Ecocert, etc.
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Think the 1st question might be the valaidity of the testing and the accuracy of report - that I’m sure the FDA is currently addressing.
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Suggest you ask for their last FDA audit.