PhilGeis
Forum Replies Created
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Apparently Lush thinks it does.
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The organic acids you’re using are pretty poor by themselves..
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Think Biocriol WS1 is a bad idea for an aerosolized product. The isothiazolinones can be sensitizers - that’s why they’re not used in leave-on cosmetics.
Sensitization in an aerosolized context could lead to anaphylaxis. -
what goes into solution
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General considerations https://cosmeticseurope.eu/files/5914/6407/8121/Guidelines_on_Stability_Testing_of_Cosmetics_CE-CTFA_-_2004.pdf
The primary elements are safety (esp. preservative efficacy) and performance stability (emulsion, esthetics, pH etc.) for regulatory - e.g. weight.
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With the contamination you mentioned, probably the latter with EDTA. Your primary fix must be in bringing GMP’s, manufacturing hygiene and possible biofilm into control..
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Piroctone olamine was used for dandruff. Hair thinning was not its intent - this is tangentdial - a potential, limited benefit. P&G never made the relevant claim.
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MurtazaHakim said:Sodium benzoate’s activity is very low at pH above 5 and liquid hand soaps usually have pH ranging from 5.5-7.5.
Re. Na benzoate, In presence of some surfactants, the pKa is effectively increased. I’ve found effect at 7 . Please look at labels - CMIT/Na Benzoate is in Head & Shoulders, Pantene, Herbal essences, Aussie - all pH well above pKa.
Lonzaserve ID is a combination of DMDM Hydantoin and CMIT - very effective but prob overkill as they share the same primary spectrum of efficacy tho discouraging adaptation. might be advisable if you’ve a resistant bug in your manufacturing system.
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Na benzoate broadens the spectrum and EDTA complexes divalent cations, esp. Ca++ to destabilize biofilm/capsule.. CMIT is primarily effective vs Gram negative - Na benzoate in surfactant context increases efficacy and broadens spectrum. Two preservatives should make it ore difficult for the microbes to adapt.
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to consumers? that’s marketing and advertising and only indirectly technical
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it’s CMIT - keep it less than 5 ppm active and combine with Nabenzoate and EDTA
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Suggest CMIT/ Na benzoate /EDTA unless you formulate to be politically-correct. Good luck with that.
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Abdullah said:@PhilGeis good point but how you claim and support it is very important especially in a product that doesn’t do what people think it does for example reducing hair fall by shampooing it.
Not sure I understand - if you haven’t support, haven’t applied some metric in development that demonstrates, the claim is fantasy - pretty common in cosmetic biz.
If you’re asking how to communicate a product benefit valid or fantasy - that’s marketing/advertising. -
MurtazaHakim said:Is proxel 106 a suitable preservative to be used for hand soaps ???
No. It’s formaldehyde with CMIT/MIT. The formaldehyde is not needed - as it shares efficacy with CMIT. It’s intended for paints coatings etc. where manufacturing contamination is typically pretty bad and the two strong preservatives help against resistance development.. Think some folks consider formaldehyde presence in head space in can discourages mold.
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Consider testing your product to any claim - rather than looking for support.
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ariepfadli said:Try with formaldehyde releaser such DMDM Hydantoin, imidazolidinyl urea, etc. They effective and safe for rinse off products
Good ones above but recommend as best Na benzoate/chloromethyl isothiazolinone /EDTA.
However these are manufacturing contaminants - appears you need major improvement in manufacturing hygiene and GMP’s. Preservatives are largely intended to protect during consumer use. -
Are you in US ?
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Abdullah pointed out you have a system. Be aware, for wipes you must challenge test the wet wipes - not just the fluid.
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No one sterilizes and you don’t need sterility. You probably don’t need to use any - are the bottles clean?
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Not sure there is a limit or at that level concern is more potential than reality.
Yup 35% by weight. -
Sodium phytate is a good chelator. Stay with it.
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Graillotion said:I never read the label on my distilled water before tonight. Is says:
Processed by: Steam distillation, microfiltration, ozonation.So is that the trifecta….as good as I could hope for from a big box store purchase, @PhilGeis ?
Ozonation helps., it’s typically used for bottled water. Go with the test
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Pharma - and worse - the damned things are so hard to culture, it takes forever to figure out the problem (discolor, clouding, slime) is microbial.
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Moderate halophiles can grow up to 20% salt and halophiles are among the contaminants of many household and industrial products - minerals/salts themselves are often the source.
Pharma makes a good point - they are heat sensitive. Boil it and seal it - or take your chances.