PhilGeis
Forum Replies Created
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btw - NaOH and Mg sulfate will likely precipitate some Mg hydroxide
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Data I’ve seen is with anionic surfactants.
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I’m only aware of phenomenon with surfactant-based products
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the products were
here’s a poster for the benzoic acid/pH efficacy. There’s also an article SOFW about 5 years ago -
Nice post Mayday. I too have had trouble with sorbate and also had little to no issue with phenoxy odor (mine at 5000 ppm or less).
One add - benzoic acid with surfactants can have efficacy well above the indicated pH from pKa. Can send some documentation
I used this in preservation (with isothiazolinones) for surfactant products face wash, shampoo, hand soaps for many years. -
EDTA won’t work - tho’ a builder would be a good idea for cleaning. It’s just a booster to preservative efficacy. Your objective for household products is to make them clean - unlike cosmetics for which micro safety in use is an issue.
Can you heat (pasteurize) product as final manuf step? -
Dawn uses isothiazolinone and phenoxyethanol - with the apparent head fake that the latter is “solvent.”
Viscosity - would NaCl work ? Might be cheaper and less prone to soap formation with food fatty acids
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Suggest phenoxy max 5000 ppm. If that isn’t effective, greater level is unlikely to help.
Sorbate as unsaturated molecule can undergo oxidation. -
You’ll not form a soap per se - but dishwashing detergents are typically alkaline. Suggest adjustment to ~ 8-9 with NaOH. You might also consider a preservative. Look at Dawn https://dawn-dish.com/en-us/how-to/what-dawn-is-made-of-ingredients
Why mag sulfate? for viscosity adjustment? -
Could “smell” may also be due to sorbic acid instability/oxidation?
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PhilGeis
MemberMarch 10, 2022 at 3:14 pm in reply to: Product contamination by which of these microorganisms can increase the pH of product?Doubt much info - but product ingredients prob would be functional - sugars, amino acids, protein,
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PhilGeis
MemberMarch 10, 2022 at 2:31 pm in reply to: Product contamination by which of these microorganisms can increase the pH of product?what product?
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PhilGeis
MemberMarch 10, 2022 at 9:33 am in reply to: What are the resources you would need to begin getting US FDA approval for sunscreen?FDA does not “approve” specific sunscreens. They are made in compliance to the relevant monograph, drug GMPs, etc.
https://www.accessdata.fda.gov/drugsatfda_docs/omuf/OTCMonograph_M020-SunscreenDrugProductsforOTCHumanUse09242021.pdf -
Prob best to examine mineral sunscreen labels of major manufacturers.
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PhilGeis
MemberMarch 8, 2022 at 11:11 am in reply to: Propylene glycol irritation. I thought this was a rather benign ingredient?Glycols at higher conc’s can irritate. It is often transient, disappearing with continued product use as iwith relevant deodorants,
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What is surfactant?
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Agree with Paprik - water activity with making controls would prob work for self life tho 70% sucrose would leave potential fungal gap. - if preserved, suggest you shoot for that target. FA releasers and phenoxy not so useful in that context. what’s pH?
With packaging - what is expectation of consumer water addition/contamination/ -
Glycerine from Sapogel + 2% is prob irrelevant - great if you could get Aw data but I know that’s not generally available.
What’s powder bioburden?
Hot fill ? Does it appears to take up water? -
The quality of their product is not the quality of your product. Can you share your risk assessment?
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MurtazaHakim said:4% w/v of CHG is the active ingredient. A formulation with such a high % of CHG should not require any other preservative.
Wrong. Or perhaps you can prove it.
To note in your “proof” - https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/outbreak-of-burkholderia-cepacia-bacteremia-caused-by-contaminated-chlorhexidine-in-a-hemodialysis-unit/85154B587466D8DD5BFC9F9971CDF95E
https://academic.oup.com/jimb/article/42/6/905/5995474?login=true
and many other such reports in google scholar.
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Not only will phenoxyethanol not cover fungi and Gram positive bacteria well enough - if diluted 1:10 as you indicate, you’ll have only 600 ppm - and inadequate level in any case.
Will you have the consumer dilute?
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what is the preservative?
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CHG is a poor preservative.
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Not “purpose”. Those are not added.
Na Carbonate is a natural contaminant of NaOH - a product of CO2 from air and NaOH.
NaCl is a feedstock for NaOH production - prob left over from that process.