PhilGeis
Forum Replies Created
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brine - saturated aq. solution - manuf is full of feces.
https://www.hou.usra.edu/meetings/modernbrines2021/pdf/6006.pdf
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What’s pH? Might need a preservative.
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Your concern is CMI stability at high pH?
Household/industrial products are typically preserved vs contamination in making, not in use. So CMI loss is not a factor. For example, the high surfactant, high pH, squeeze package of hand dish wash largely eliminate in-use contamination risk because microbes that can grow under those conditions are not found in use. They adapt in the relatively poorly controlled (vs cosmetic) manufacturing systems and come in with ingredients such as salt.
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what’s pH?
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0.94 - about at the edge of Gram negative inhibition, not enough for other bacteria and fungi.
not picking on you - but how “microbiome friendly”?
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add something for fungi and Gram + bacteria
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What “efficacy” is that? What test and what data?
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neither needs a preservative
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Sure!
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This reply was modified 1 month, 3 weeks ago by PhilGeis.
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This reply was modified 1 month, 3 weeks ago by
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bisulfite also reacts with formaldehyde, reducing preservative capacity
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Please don;t use “Parfum” preservative. You’ve no idea what’s in it, it’s safety or consistency.
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This is not a shampoo - it’s spoiled fruit juice
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Twos simple answer - (1) forget the silly Naticide and 2) speak of specific chemicals - not commercial products.
Phenoxy/EHG with Benzoate at a lower pH and EDTA should work. Add sorbic if you use that combination.
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I am very sorry, you do not salvage the batch. If it failed to meet (micro) spec., it is adulterated. You could do an investigation to determine if somehow the micro hit is not legit. Failing that there is nothing you can do.
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As ketchito said and if you’re in US, your client is marketing and you manufacturing an unapproved new drug. FDA banned triclosan 8 years ago.
Separately, you should be a registered drug manufacturing facility.
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OK - maybe the Shisedo test. It’s BS but it’s out there.
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Sure wonder at the stability - sorbate can be oxidized in water solution usually give a yellowish tint.
I’d sure ask the supplier for stability data.
https://pubs.acs.org/doi/abs/10.1021/jf60232a072
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Thanks - got it
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Sure
“Parfum : 0.5%”, if this is Natacide, please do not use it.
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Thanks
Ayuverdic is as much philosophy as “medicine”. As with China and Traditional Chinese Medicine, it is as much an accepted medical practice in India as Western science-based medicine.
Based primarily on legend, faith and 3rd party testimony, there is little to no application data supporting. A typical example one finds in supporting literature - e.g. agar zone of inhibition = therapeutic antibiotic efficacy vs. systemic disease.
Review of Ayuverdic medicine found ~20% to present toxic levels of Arsenic, Mercury, Lead https://pubmed.ncbi.nlm.nih.gov/18728265/
To the material in question - a lot of maybe’s - - and maybe not. By Western science null hypothesis - it doesn’t work until proven to work.
- May have anti-dandruff potential
- May help with wound healing
- May have an anti-hair fall potential
- Maybe anti-inflammatory
- May have potential antifungal activity
- May have antibacterial activity
- May be potentially a good anti-oxidant
- May help with hair fall
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Shampoo and conditioner and that is not a cosmetic and may be hiding ingredients. This is a credible product?
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Use 2500 ppm of each
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I wouldn’t unless you can confirm stability. Benzoate should be stable, not so sure the sorbate, and ironically you may need a preservative for the preservative solution.
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Depends the pH established. This is pretty certain contamination. Tap water typically includes pseudomonads and the preservative system at its best/any pH is poor against it.. Wonder at hair feel if. any hardness
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Apparent “preservation” is silly. Sodium bicarbonate will offer an alkaline pH - the sorbate benzoate require an acidic pH for any efficacy. Also wonder how this stuff works in hard water.
Is one tablet used each time one shampoos or diluted in another vessel for use over some time period?