otherhalf
Forum Replies Created
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@perry
If you read the papers I posted you already know the answer to the 3 k questions.
And yes, as scientists there is a need to separate waters, at the same time it is disappointing to see the cognitive dissonance between knowing what works and cash cow what doesn’t.
I guess the science just isn’t reaching the consumers, allowing for quackery to reach everyone’s homes.
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What benefit? I still haven’t found anything about it.
Can someone post sources?
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@zinc
Yup I know about that paper.
The size does seem to make a huge difference!
But for microsurgery even the biggest one greatly reduced the scar tissue formation.
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@perryThe papers I proposed in my last post are just the demonstrate that these compounds actually can modulate cell metabolism, not to prove that they cure cancer ah ah ahAlso, I tend not to trust on kligman work after the 90’s when it was found that he forged data and was banned by the fda.He created retin a i will always be thankfulMy skin would not be what it is without it.But, take his opinion with a grain of salt.I do know of a few actives that work. And fortunately there other people that also believe in them and put out products that are science backed.
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What is that compound? What is it supposed to do?
Serobiologique has some pretty awesome things
Tell me more!
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@perry
This is the cellular function of ha
http://www.ncbi.nlm.nih.gov/m/pubmed/24658508/?i=3&from=hyaluronic%20acid%20skin%20metabolism
http://www.ncbi.nlm.nih.gov/m/pubmed/24487587/?i=9&from=hyaluronic%20acid%20skin%20metabolismRegarding on how to test the effect, the ideal would be a scrape and seq.
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Exactly what I meant! On point!
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@perry
It is quite demoralizing to see cosmetics under a purely economical light. It seems like it is more snake oil than it needs to be.
You are also mistaken on your knowledge of biological actives
I would suggest starting with this review:
http://www.ncbi.nlm.nih.gov/m/pubmed/23369589/?i=6&from=topical%20vitamin%20c%20metabolismAnd this paper
http://www.ncbi.nlm.nih.gov/pubmed/23691100 Vitamin c is taken up by glu4 receptores it really does not need a deep effect because of cell-cell communication.
Regarding the hair:
I mentioned in my own post, you can only act on growth, but the mentioned growth factor does not exist. -
@perry
None of the compounds you mentioned have any action at the DNA level, just at overall fibre deposition and lipidic composition so I guess they are not comparable at all.
They both have benefits but they can’t be put at the same level.
Also regarding the effect of the hyaluronic acid on the skin: it is a bit beyond the functions of humectant or moisturizer, by intercalating the extracellular matrix it is able to improve cell cell communication and in this way promote proliferation hence it’s use in neural surgery patches and cartilage recovery.
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Hair is kind of a dead end, it is dead.
You either prevent damage or just manage it.
Edit: also, I never heard in my field of such a thing called human hair growth factor.
Sexual hormones, neurotrophins and kgf are min inducers of growth (hence on growth, not restoration)
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@perry
Vitamin c changes fibroblast metabolism
Vitamin e changes metabolism
Q factors change metabolism
These are just a few examples.
What do you mean?
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MPbio and sigma sell the acid for 1/4 of the price.
It is closer to one dollar per gram.
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First a bit on sebum:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835908/Properties of honey
http://www.ncbi.nlm.nih.gov/m/pubmed/23762853/?i=3&from=honey%20acneOlive oil (if you read the first paper you’ll already know about squalene)
http://www.ncbi.nlm.nih.gov/m/pubmed/23449131/?i=1&from=olive%20oil%20acneI am sorry about not including propolis, the supporting papers are very poor in quality.
I would say honey+occlusion you made an hydrocholoid bandage of sorts.
Be careful if you get a purge cycle when you stop using it.
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Edit: I used to get my ferulic acid from sigma.
The mobile layout of the forum is weird.
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@bobz: clap clap clap clap!
the biology side agrees so much with that statement. But hey, who can publish negative results?
Nobody unfortunately.
Cleansers should remove dirt and sebum. That is pretty much it.
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Oh wow
In case you guys decide to do something with it, some scientists would be really happy to sample a product. (puts hand really high)
The poor person serum is just the glycerin, thermal water and vita c. It is under 0. 5 dollars but needs to be made every couple of weeks
I used to get mine from sigma but that was the fancy cell compatible one.
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I am sure they can, they just haven’t yet in a way that can remotely compete with what you find in the US.
Or they are probably like noreva. All the right things, no way to reach costumers lol.
But like I asked earlier in the thread please! If you are aware of an European dupe please let me know! It is a hassle to order stuff from the us for the months I am stuck in Europe
Edit: and BTW! I feel like I am completely derailing your forum, I am really sorry, please let me know if you would like me to tone down my participation!
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Correct me if I am wrong,
Amodimethicone is one of the hard to wash but not really build up silicones right?
Won’t the first layer just repel the second layer?
So, you would need anionic or zwitterionic surfactants but it would at least not build up too much.
If sold together with a weekly clarifier it would be a pretty awesome product, best of both worlds and it would also appeal to the “nopoo” people.
(sorry we used some of these things to grow embryos so my knowledge is very basic)
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And one of my favorite papers on the subject:
http://www.nature.com/jid/journal/v125/n4/full/5603565a.html
If I could get my hands on some!
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Omg yes please!
Give me a second! I’ll pull out all the literature!
Please please please compete with the absurd prices of skinceuticals lierac and sesderma!
Gonna get references,
Do you want to make toner? Serum? Moisturizer?
The packaging is really important.
Sorry not chemist, molecular bio with a love for all things skin!
H acid:
http://www.ncbi.nlm.nih.gov/m/pubmed/25260051/?i=2&from=hyaluronic%20acid%20topical%20skin
http://www.ncbi.nlm.nih.gov/m/pubmed/24847403/?i=5&from=hyaluronic%20acid%20topical%20skin
http://www.ncbi.nlm.nih.gov/m/pubmed/24688623/?i=11&from=hyaluronic%20acid%20topical%20skin
http://www.ncbi.nlm.nih.gov/m/pubmed/23884503/?i=3&from=hyaluronic%20acid%20acneFerulic:
http://www.ncbi.nlm.nih.gov/m/pubmed/24941338/?i=2&from=ferulic%20acid%20skinhttp://www.ncbi.nlm.nih.gov/m/pubmed/24577928/?i=4&from=ferulic%20acid%20skin
http://www.ncbi.nlm.nih.gov/m/pubmed/24373826/?i=7&from=ferulic%20acid%20skin
Add vitamin c to the mix and so many people will be able to stop using their crappy home made serums.
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No problem zinc
I really hope you find cleanser changing ingredient.
It is pretty impressive what a good cleanser alone combined with ocm can do to change a skin type.
The way some cleansers change the skin irritation is amazing.
If you come up with a way to sell the whole double package you would get many many many happy and loyal costumers to your product.
I haven’t even found something like that in the Asian markets.
How that niche wasnt taken I don’t know.
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Because of what you describe the European market of cosmetics is suffering a shift.
People that know a bit more about skin care are refusing to buy products from the EU.
(the avene formula change was just an example).
Iherb, vitacost and paula’s choice for instance are becoming some of the biggest, when it comes to put cosmetics in people’s homes.
It is a quite interesting time. I would love to see the EU follow the us example.
Of course I m seeing things from a very different angle from your own.
I am on the side of people that just want things that work and no bullcrap.
The us owns the best developed products.
There is no cream in the EU that I would buy right now lol. Neither any of the people I know.
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It has all the right ingredients ( hyaluronic acid, ceramides and niacinamide) at amazing ph.
The texture makes it very suitable and adaptable to a very broad range of skin types (Fitzpatrick rating independent)
I just wish there were more likewise products.
The second best I found so far have the most horrible marketing statement and way to reach clients so they will never leave anonymity. Perfect price range to be ubiquitous as well, just sad.
Edit: just to add, and please keep in mind that these are small scientist at play experiments we did during incubation periods of our own experiments.
Water alone brought the skin phs higher than 6.5, those that but a toner on their face got the pH back to under 6 in less than 30 minutes, for othose without the toner it took as much as 5 hours.
I thought it was pretty cool to see how much cosmetics can do for you.
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Wow, that makes me really sad
Think you for being so frank. I am going to double my attention on what I buy
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@ Ruben
I don’t make any cosmetics ah ah
I am just interested in them, this waiver a year ago when I was able to get samples from the actual products.
There is knowledge from the biology side that I don’t know how to translate to the chemical side since it is out of my area of expertise.
I am just here as an amateur with an interest.
@ Marc
That makes senseJust another question!
From a theoretical stand point cerave pm is one of the most balanced well formulated facial moisturizers around for its price range.
Is there any European equivalent? If not, why?
Thank you!