[myalcin]

@drbob@verdient.biz Hi Dr.Bob, 
Yes the formula is stable we know that. Because it passed from all of the stability tests(long time like 3 monts etc.) and yes I think we have problem at the process some times. Ok I wonder which fast quality control test method we must do after every batch in the production for finding this problem? Freeze/thraw test is too long. (six days) wait -10C 24 hours and wait normal room temp 20-25C 24 hours. This cycle must be 3 times for correct result. Can we do this test like that for one period wait -10C 12 hours and then 20-25°C 12 hours? or how can we find if there is the stability problem on my batch or not? Which another method is more quickly then this test? Thank you for your interesting.  

[myalcin]

Hi Dr.Bob,
Yes the formula is stable we know that. Because it passed from all of the stability tests(long time like 3 monts etc.) and yes I think we have problem at the process some times. Ok I wonder which fast quality control test method we must do after every batch in the production for finding this problem? Freeze/thraw test is too long. (six days) wait -10C 24 hours and wait normal room temp 20-25C 24 hours. This cycle must be 3 times for correct result. Can we do this test like that for one period wait -10C 12 hours and then 20-25°C 12 hours? or how can we find if there is the stability problem on my batch or not? Which another method is more quickly then this test? Thank you for your interesting.

[myalcin]

But freeze thraw test is too long. If we apply this test as three cycle at our control system we should have wait six days before transportation. We do this test at first time for controlling formulary stability. And the formulary passed it. We have problems at continuous production

[myalcin]

Hi Dr.Bob,

There is also interesting thing. We tested this product as a bulk. We measured its viscosity value, pH, etc. And did centrifuge test at 3000 rpm, 50 C 30 min. the product passed all if these tests. And we filled it but after 5-6 months it would be like that How can we understand this problem before filling.

[myalcin]

Hi Bill, we mix each phase (water and oil) at 80 C.

[myalcin]

Hi Dr.bob,
Could you see above photo. We met this problem sometimes. Can we save this finished product by applying something or is it waste? If we can save how can we do? And Your suggestion adding ultrez 1, can it be solved our problem? Sometimes our viskosity value arrives 130.000-150.000. I thing our problem is not viskosity problem for stabilitiy.

[myalcin]

Thanks for your interest. We use homegenizer 2 or 3 times for several minutes during cooling. We read the Evonik’s document. Although our formula and process is same with the documentation, we have this problem. Can we save this finished product or is it a waste?

[myalcin]

Hi, thank you for your interest. We use the cream base from evonik;  protegin wx which include petrolatum, ozokerite, hydrogenated castor oil, glyceryl ısostearate, polyglyceryl-3 oleate. Our cream spekts; pH is 5,5-6,5 and viscosity is 80.000-120.000.