[jackleon80s]

MarkBroussard said:

@jackleon80s

Take a look at Aquafor and CeraVe products … you will find both creams and ointments that contain Petrolatum … that should give you some insight.

I’m trying to achieve something like Neosporin, its consistency is still somewhat like petrolatum, however I do not think it is emulsified with a water phase. It may not be possible. I will check the ingredients.

[jackleon80s]

MarkBroussard said:

@jackleon80s

Yes, treat Petrolatum like an oil in an emulsion.  The Petrolatum will function as a barrier film former when the emulsion is applied to the skin.

Is there an emulsifier that is more suitable for petrolatum, that is one that will preserve most of its physical properties, and not turn it into a cream? Thanks again

[jackleon80s]

MarkBroussard said:

@jackleon80s

If you are using Petrolatum as a base for an ointment the easiest approach is to use oil soluble ingredients.  If you want to use it in an emulsion, melt the Petrolatum with your oil phase and proceed as usual.

Thanks for your response. So from my understanding petrolatum would behave like an oil. If it can be emulsified with the water phase, I am wondering which properties the end product would have? I am unsure if I ever seen a petrolatum based emulsion.

[jackleon80s]

Perry said:

No, it is not legal. Ketoconazole is a drug active.  A prescription is required thus making it illegal to sell as a cosmetic.

There are some products that contain ketoconazole and are available online (amazon) for purchase without a prescription. How can this be possible?

[jackleon80s]

em88 said:

I will write you privately, tomorrow (it’s too late now in my country)  and will direct you to the right problems so you can understand and solve your formulation by yourself.

Thank you, looking forward!

[jackleon80s]

Belassi said:

Took me about 30 seconds. Or less.

To what limit do patents for formulations are in effect?

Does this patent prevent any other product created and put on the market containing both ketoconazole and butylated hydroxtoluene? Is this why Nizorol is one of the very few shampoos containing ketoconazole?

[jackleon80s]

em88 said:

Microformulation said:

No, and only for the reason that any Formulator MUST know how to check a patent.  If you are selling a product, a patent search is part of the Product Development phase.

Go to Google patents and do a search. It will help in this case as well as future products. https://patents.google.com/

Are you kidding me? How did you assume, I did not know how to search for patents? As a researcher, citations are a must when writing other’s work!
I only asked for the patent number, 1 because you already red/had it, and 2 I was on my phone. 
For your information, Google patents is not the best database for patents.
Now we should be afraid even to ask for the information source? That’s pathetic. 
Back to the topic. That patent had a few “mistakes”, probably to avoid publishing information.
Ketoconazole shampoos have two major problems, one is solubility and the second is stability of the api. Both of these problems can be solved. There are a few threads here (I’m on mobile and I can’t find right now the search option in this forum to link the threads) that may provide some info.. Since the level of egoism is so high and there are so many quick smart people in this thread I’m not going to write my personal research here (and I have already solved these problems). 

Why do people bother to help when they don’t like doing it,resulting in the end being impolite?

Thanks, this is the type of reply I was looking for. I know it’s not easy to formulate with Ketoconazole, and I have indeed did several searches to find how to formulate it into a shampoo with no success. 

If you can point me in the right direction on how to solve these two major problems, that would be very helpful.

[jackleon80s]

Microformulation said:

You can answer these questions and more by doing a simple Google search. The J&J patent describes the Formulation.

I did do many google searches and did not find anything. This is why I decided to ask here in the first place.

[jackleon80s]

So then if Ketoconzaole is oil soluble then any oil can be used and emulsified with water to produce a evenly distributed product.

If that is the case then detergent would not even be required as just oil, water and a emulsifier should be sufficient, is this correct?

[jackleon80s]

Sorry, Pharma said:

Detergents .

Can you clarify please?

[jackleon80s]

Update - maybe a cookie press maker gun or a icing piping bags may work. Anyone know anything better?

[jackleon80s]

Euxyl PE 9010. Any remarks?

[jackleon80s]

Will it degrade emulsion?

[jackleon80s]

The oil tends to heat much faster than the water, and when I remove it from heat it cools down by the time the water phase reaches the same temperature. 

[jackleon80s]

I need a higher level to solubilize 8% plant oils?

[jackleon80s]

Isopropyl Alcohol and Propylene Glycol may be decreasing viscosity, that is why I used a higher percent of carbomer to achieve the thickness I wanted. I will try to use my electric stirrer and add the carbomer during emulsion this time to see if it is more stable. If it is not, maybe increasing the emulsifier concentration will help. I am out of ideas after that.

[jackleon80s]

It has been shown in studies to increase skin penetration along side Isopropyl Myristate

[jackleon80s]

I am using prenuetralized carbomer from lotioncrafter.com that does not state what it is neutralized with.

[jackleon80s]

I use Optiphen Plus for the preservative. Why must I remove the alcohol?

I tried using xanthan gum instead of carbomer and I do not notice the problem, however when I apply xanthan gum on skin it begins to create flakes.

[jackleon80s]

So a fragrance is exclusively a scent ingredient only, used to modify the smell of the final product?

[jackleon80s]

I was able to get it to thicken by using 1% carbomer at the 5.5 pH level. I was hesitant to use more than 0.5%

[jackleon80s]

I will be heating both the water and oil phases to 70° C and then once the emulsion cools down to under 50° C I will add my herbal extracts and Allantoin.

I am assuming this will not interfere with the emulsion because emulsion only involve water and oil, does this mean that all water soluble ingredients can be added during or after emulsion? Since the water concentration in my formula is higher than oil, there should be enough water for the ingredients to disperse to anyway?

Is there an advantage in placing the ingredients into the water phase before emulsion?

Thanks